Variable | Dyskinesias | P Value | Motor fluctuations | P Value | |||
---|---|---|---|---|---|---|---|
Yes / no | OR (95% CI) | Yes / no | OR (95% CI) | ||||
Age at onset (yr) | ≥59 | 30 / 420 | Reference | 0.15 | 68 / 382 | Reference | 0.13 |
<45 | 11 / 49 | 2.32 (1.00 – 5.41) | 14 / 46 | 1.20 (0.57 – 2.53) | |||
45-58 | 22 / 205 | 1.31 (0.70 – 2.46) | 55 / 172 | 1.63 (1·02 – 2·61) | |||
PD duration (yr) | <5 | 15 / 399 | Reference | 0.36 | 30 / 384 | Reference | 0.02 |
5-9 | 28 / 188 | 1.88 (0.79 – 4.51) | 64 / 152 | 2.52 (1.31 – 4.85) | |||
≥10 | 20 / 87 | 1.82 (0.59 – 5.59) | 43 / 64 | 2.46 (1.05 – 5.76) | |||
Hoehn -Yahr stage | <3 | 38 / 540 | Reference | 0.03 | 76 / 502 | reference | <0.001 |
≥3 | 35 / 134 | 2.03 (1.08 – 3.82) | 61 / 98 | 2.58 (1.62 – 4.11) | |||
LD dose, mg/d | <400 | 16 / 370 | Reference | 0.02 | 39 / 347 | Reference | 0.002 |
400-599 | 21 / 149 | 2.48 (1.20 – 5.13) | 37 / 133 | 1.69 (0.99 – 2.91) | |||
≥600 | 26 / 155 | 2.44 (1.20 – 4.98) | 61 / 120 | 2.48 (1.49 – 4.14) | |||
LD/DCI duration (yr) | <2 | 14 / 294 | Reference | 0.44 | 23 / 285 | Reference | 0.07 |
2-4 | 15 / 215 | 1.04 (0.47 – 2.34) | 36 / 194 | 1.58 (0.86 – 2.87) | |||
≥5 | 34 / 165 | 1.73 (0.66 – 4.51) | 78 / 121 | 2.42 (1.14 – 5.12) | |||
Months to initiate | ≤12 | 27 / 339 | Reference | 0.87 | 66 / 300 | Reference | 0.66 |
LD/DCI use | >12 | 36 / 439 | 0.95 (0.49 – 1.83) | 71 / 300 | 0.89 (0.54 – 1.48) | ||
Initial treatment | non LD/DCI | 22 / 119 | Reference | 0.04 | 35 / 106 | Reference | 0.42 |
LD/DCI only | 22 / 259 | 0.46 (0.22 – 0.95) | 53 / 228 | 0.76 (0.42 – 1.36) | |||
LD/DCI + others | 19 / 296 | 0.41 (0.19 – 0.87) | 49 / 266 | 0.67 (0.37 – 1.22) |