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Table 2 TargetScan analysis of the most deregulated miRNAs

From: Independent effects of sham laparotomy and anesthesia on hepatic microRNA expression in rats

 

#

miRNA

Strongest expression change

Putative targets

A. miRNAs similarly deregulated following PH and SL

1

rno-miR-105

1,61

N/A

2

rno-miR-466c

1,53

HLF, NFIB, HHIP

3

rno-miR-483

0,56

IGF1, SMAD4, DLC1

4

rno-miR-133b

0,59

SP3, MAP3K3, FOXC1

5

rno-miR-598-5p

1,4

N/A

B. miRNAs with opposite regulation after PH and SL

1

rno-29a

0,78

TET1, VEGFA, IGF1

C. miRNAs deregulated after SL but not following PH

1

rno-miR-708

1,55

NRAS, KRAS, PPARA

2

rno-miR-511

1,47

N/A

3

rno-miR-224

1,46

SMAD4, SP7, HOXD10

4

rno-miR-337

1,42

NLK, MET, CDK6

 

5

rno-miR-484

0,61

BCL2, IRS2, PHKB

  1. The five miRNAs that showed the strongest expression changes from each group in Table 1 were included for putative target analysis using the TargetScan rat algorithm (http://www.targetscan.org; Release 6.2, June 2012). The table provides a selection of putative targets. The ranking of microrna expression changes was performed according to the microarray data from Table 1 considering significant expression changes at all time points. For group A expression changes in the PH but not the SL group were used (since these were considered more relevant to the biological mechanisms of liver regeneration). PH – partial hepatectomy, SL – sham laparotomy, N/A – not available.