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Table 10 Amino acid substitution of the NS1-NLS AND ISG15 binding site

From: Genetic characterisation of influenza B viruses detected in Singapore, 2004 to 2009

 

NS1 nuclear localisation sequence

ISG15 binding site

46

        

56

34

97

101

 

I

B Lee 40

D

R

L

H

R

L

N

R

K

L

E

F

I

E

 

DSO 090114 2004

.

.

.

.

.

.

.

.

.

.

.

.

.

.

 

DSO 090124 2004

.

.

.

.

.

.

.

.

.

.

.

.

.

.

 

DSO 090131 2004

.

.

.

.

.

.

.

.

.

.

.

.

.

.

 

DSO 090133 2004

.

.

.

.

.

.

.

.

.

.

.

.

.

.

 

DSO 090134 2004

.

.

.

.

.

.

.

.

.

.

.

.

.

.

 

DSO 090136 2004

.

.

.

.

.

.

.

.

.

.

.

.

.

.

 

DSO 090138 2004

.

.

.

.

.

.

.

.

.

.

.

.

.

.

II

B Yamagata 16 1988

.

.

.

N

.

.

.

K

.

.

.

L

V

.

 

B Victoria 02 1987

.

.

.

N

.

.

.

K

.

.

.

L

.

.

 

B Singapore 04 1991

.

.

.

N

.

.

.

K

.

.

.

L

V

.

 

B Singapore 11 1994

.

.

.

N

.

.

.

K

.

.

.

L

V

 

III

DSO 090117 2004

.

.

.

N

.

.

.

K

.

.

.

L

.

.

 

DSO 050143 2005

.

.

.

N

.

.

.

K

.

.

.

L

.

G

 

DSO 050540 2005

.

.

.

N

.

.

.

K

.

.

.

L

.

G

 

Rest of DSO Specimens

.

.

.

N

.

.

.

K

.

.

.

L

.

.

 

B Singapore 22 1998

.

.

.

N

.

.

.

K

.

.

.

L

.

.

 

B Singapore 31 1998

.

.

.

N

.

.

.

K

.

.

.

L

.

.

 

B Singapore 35 1998

.

.

.

N

.

.

.

K

.

.

.

L

.

.

 

Vacc04S B Hong Kong 330 2001

.

.

.

N

.

.

.

K

.

.

.

L

.

.

 

Vacc0405N 05S B Jilin 20 2003

.

.

.

N

.

.

.

K

.

.

.

L

.

.

 

Vacc0405N 05S B Shanghai 361 2002

.

.

.

N

.

.

.

K

.

.

.

L

.

.

 

Vacc0608NS B Malaysia 2506 2004

.

.

.

N

.

.

.

K

.

.

.

L

.

.

 

Vacc0506N B Jiangsu 10 2003

.

.

.

N

.

.

.

K

.

.

.

L

.

.

 

Vacc0809NS B Florida 4 2006

.

.

.

N

.

.

.

K

.

.

.

L

.

.

 

Vacc0912NS B Brisbane 60 2008

.

.

.

N

.

.

.

K

.

.

.

L

.

.

 

Vacc1213N B Wisconsin 01 2010

.

.

.

N

.

.

.

K

.

.

.

L

.

.

  1. Amino acids 46–56 correspond to the NLS of the NS1 protein. I: Specimens clustering in cluster I of the NS phylogenetic tree. II: Specimens clustering in cluster II of the NS phylogenetic tree. III: Specimens clustering in cluster III of the NS phylogenetic tree. Rest of DSO Specimens: rest of specimens sequenced in this study not individually listed in this table. Identical amino acids are marked by a dot (.).
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BMC Research Notes

ISSN: 1756-0500

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