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Table 2 Non nucleoside RT inhibitor (NNRTI) resistance mutations: percentages occurrence in patients treated with duo nucleoside RT inhibitor plus NNRTI first -line antiretroviral (ARV) regimens

From: HIV type 1 drug resistance patterns among patients failing first and second line antiretroviral therapy in Nairobi, Kenya

ARV Regimen

n.

103

106

181

188

190

A98

V108

Y184

K70

NNRTI

NRTI

 

NS

M

C

LCH

ASEQ

G

IV

V

KT

  

60

n (%)

n (%)

n (%)

n (%)

n (%)

n (%)

   

Efavenz (EFV) containing regiments

          

EFV

TDF/3TC

3

1

-

1 (33.3)

-

1 (33.3)

  

1 (33.3)

1 (33.3)

 

AZT/3TC

15

5 (33.3)

-

-

-

-

    

Sub-Total

 

18

6 (30)

-

1 (5.6)

-

1 (5.6)

    

Nevirapine (NVP) containing regiments

          

NVP

D4T/3TC

4

-

-

-

-

-

-

   
 

TDF/3TC

3

2 (66.7)

-

-

-

1 (33.3)

-

   
 

AZT/3TC

18

1 (11.1)

-

-

1 (5.6)

2 (11.1)

-

   

Sub-Totals

 

25

3 (19.2)

-

-

1 (3.8)

3 (11.5)

-

   

PI

           

Lopinavir (LPV)/Ritinovir containing regiments

         

LPV/R

ABC/DDI

1

-

-

1 (100)

-

-

1 (100)

   
 

ABC/3TC

2

-

-

-

-

-

-

   
 

AZT/3TC

7

-

-

-

-

-

-

   
 

AZT/DDI

5

1 (20)

1 (20)

-

-

-

-

1 (20)

  
 

TDF/ABC

2

1 (50)

 

-

-

1 (50)

-

 

1

 

Sub-Totals (n = %)

 

17

2 (10)

1 (5)

1 (5)

-

2 (10)

1 (5)

 

2

 

Totals

 

60

11 (18.3)

1 (1.6)

2 (3.2)

1 (1.6)

6 (9.4)

1 (1.6)

1 (1.6)

1 (1.6)

1 (1.6)