The genetic association study between polymorphisms in uncoupling protein 2 and uncoupling protein 3 and metabolic data in dogs

Table 2 Genotyping data and interbreed analysis of DNA polymorphisms in UCP3

UCP3 DNA polymorphism	Genotype	Number of samples				Allele frequency
UCP3 DNA polymorphism	Genotype	Shiba	Shetland sheepdog	p	Allele	Shiba	Shetland sheepdog
-4399C/T	CC	29	30	NS	C	0.98	1.00
	CT	1	0	CC vs CT + TT	T	0.02	0.00
	TT	0	0	CC vs CT + TT
-4339T/C	TT	0	4	p < 0.05	T	0.07	0.37
	TC	4	14	TT + TC vs CC	C	0.93	0.63
	CC	26	12	TT + TC vs CC
-4160G/A	GG	30	30	ND	G	1.00	1.00
	GA	0	0		A	0.00	0.00
	AA	0	0
-4010C/T	CC	18	13	NS	C	0.75	0.70
	CT	9	16	CC vs CT + TT	T	0.25	0.30
	TT	3	1	CC vs CT + TT
-930T/C	TT	0	4	p < 0.05	T	0.07	0.37
	TC	4	14	TT + TC vs CC	C	0.93	0.63
	CC	26	12	TT + TC vs CC
-803C/T	CC	30	30	ND	C	1.00	1.00
	CT	0	0		T	0.00	0.00
	TT	0	0
143A/C	AA	20	30	p < 0.05	A	0.82	1.00
	AC	9	0	AA vs AC + CC	C	0.18	0.00
	CC	1	0	AA vs AC + CC
IVS3+26T/C	TT	10	13	NS	T	0.57	0.70
	TC	14	16	TT vs TC + CC	C	0.43	0.30
	CC	6	1	TT vs TC + CC
IVS3+69G/A	GG	18	13	NS	G	0.75	0.70
	GA	9	16	GG vs GA + AA	A	0.25	0.30
	AA	3	1	GG vs GA + AA
IVS3+121T/C	TT	29	14	p < 0.05	T	0.98	0.67
	TC	1	12	TT vs TC + CC	C	0.02	0.33
	CC	0	4	TT vs TC + CC
IVS5-115G/C	GG	10	4	NS	G	0.55	0.37
	GC	13	14	GG + GC vs CC	C	0.45	0.63
	CC	7	12	GG + GC vs CC
IVS5-100T/C	TT	18	13	NS	T	0.75	0.70
	TC	9	16	TT vs TC + CC	C	0.25	0.30
	CC	3	1	TT vs TC + CC
838T/C	TT	28	30	NS	T	0.97	1.00
	TC	2	0	TT vs TC + CC	C	0.03	0.00
	CC	0	0	TT vs TC + CC
1106delAAG	ins ins	18	13	NS	ins	0.75	0.70
	ins del	9	16	II vs ID + DD	del	0.25	0.30
	del del	3	1	II vs ID + DD

I: insertion, D: deletion. IVS: intervening sequence.
p-values were calculated by Fisher’s exact test. p < 0.05 NS:not significance. ND: not detection.

ISSN: 1756-0500