Table 2 HLA-B27 variants associated with cocaine-associated agranulocytosis
From: Genetic determinants of cocaine-associated agranulocytosis
SNP haplotype | Cases (N = 8) | Controls (N = 26) | Odds ratio (95% CI) | P value |
|---|---|---|---|---|
HLA-B27 | 9.2 (1.54–54.6) | 0.017 | ||
+, no. (%) | 5 (62.5) | 4 (15.4) | ||
−, no. (%) | 3 (37.5) | 22 (84.6) | ||
rs4349859—dominant model | 9.2 (1.54–54.6) | 0.017 | ||
A_, no. (%) | 5 (62.5) | 4 (15.4) | ||
GG, no. (%) | 3 (37.5) | 22 (84.6) | ||
rs4349859—additive genetic model | 0.017 | |||
AA, no. (%) | 1 (12.5) | 0 | ||
AG, no. (%) | 4 (50) | 4 (15.4) | ||
GG, no. (%) | 3 (37.5) | 22 (84.6) | ||
rs13202464—dominant model | 6.8 (1.11–41.0) | 0.042 | ||
G_, no. (%) | 6 (75) | 8 (30.8) | ||
AA, no. (%) | 2 (25) | 18 (69.2) | ||
rs13202464—additive genetic model | 0.011 | |||
GG, no. (%) | 2 (25) | 0 | ||
AG, no. (%) | 4 (50) | 8 (30.8) | ||
AA, no. (%) | 2 (25) | 18 (69.2) |