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Table 3 Comparison of clinical characteristics between CD alone vs. with CD and EoE

From: Eosinophilic esophagitis associated with celiac disease in children

Clinical characteristics

CD (n = 50) mean ± SD or n (%)

CD and EoE (n = 6) mean ± SD or n (%)

P value

Demographics

 Age at diagnosis (years)

10.5 ± 4.3

11.6 ± 1.6

0.536

 Gender

  Male/Female

17 (34)/33 (66)

5 (83)/1 (17)

0.030

 Race

  Caucasian/Other

48 (96)/2 (4)

5 (83)/1 (17)

0.293

  Duration of symptoms (months)

13.8 ± 14.6

15.9 ± 12.2

0.738

 History of allergies

  Asthma

2 (4)

1 (17)

0.293

  Food allergy

8 (16)

4 (67)

0.016

 Presenting symptoms

  Abdominal pain

27 (54)

4 (67)

0.682

  Dysphagia

0 (0)

1 (17)

0.107

  Failure to thrive

12 (24)

3 (50)

0.326

  Diarrhea/Constipation

18 (36)

0 (0)

0.162

 Endoscopy findings

  Normal esophagus

50 (100)

0 (0)

<0.0005

  Ringed esophagus

0 (0)

1 (17)

0.035

  Esophageal mucosal furrows

0 (0)

5 (85)

0.0005

  White plaques in esophagus

0 (0)

4 (67)

0.001

  Normal duodenum

24 (48)

4 (67)

0.669

  Scalloping duodenum

25 (50)

2 (33)

0.671

 Histopathological findings

  TTG IgA (U/mL)

164.4 ± 129.2

248.7 ± 82.4

0.058

  Esophageal eosinophilia

1.1 ± 2.4

42 ± 20

0.0001

 Marsh score

  1

8 (16)

0 (0)

  2

8 (16)

2 (33)

  3a

16 (32)

0 (0)

  3b

18 (36)

4 (67)

  1. CD celiac disease, EoE eosinophilic esophagitis, TTG IgA anti-tissue transglutaminase antibody IgA, SD standard deviation.