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Table 2 Baseline characteristics by antibiotic

From: Risk factors for kidney injury during vancomycin and piperacillin/tazobactam administration, including increased odds of injury with combination therapy

Baseline patient characteristic

Vancomycin (N = 101)

Piperacillin–tazobactam (N = 26)

Combination (N = 101)

p value (vanc vs piptazo)

p value (vanc vs combV/P)

p value (piptazo vs combV/P)

p value (overall)

Age: mean (sd)

47.00 (15.85)

47.58 (13.22)

50.71 (15.11)

   

0.21

Female sex (%)

39 (38.61 %)

9 (34.62 %)

32 (31.68 %)

   

0.59

African American (%)

84 (83.17 %)

16 (61.54 %)

82 (81.19 %)

0.02*

0.71

0.03*

0.04

CrCl in ml/min: mean (sd)

79.61 (36.35)

75.33 (36.12)

68.22 (26.70)

   

0.08

Number of nephrotoxic agents

      

0.98

 0 agent

63 (63.00 %)

17 (65.38 %)

64 (63.37 %)

    

 1 agent

29 (29.00 %)

6 (23.08 %)

31 (30.69 %)

    

 2 agents

6 (6.00 %)

3 (11.54 %)

6 (5.94 %)

    

 3 agents

2 (2.00 %)

0

0

    

Number of comorbidities

   

0.26

0.0012*

0.0026*

0.0006

 0

46 (45.54 %)

16 (61.54 %)

26 (25.74 %)

    

 1

34 (33.66 %)

5 (19.23 %)

36 (35.64 %)

    

 2

17 (16.83 %)

4 (15.38 %)

34 (33.66 %)

    

 3

4 (3.96 %)

1 (3.85 %)

5 (4.95 %)

    

BMI: mean (sd)

26.75 (9.72)

30.27 (10.05)

26.07 (8.23)

   

0.20

IV contrast

23 (22.77 %)

3 (11.54 %)

24 (23.76 %)

   

0.39

Aminoglycoside

5 (4.95 %)

0

3 (2.97 %)

   

0.44

NSAID

13 (13.00 %)

9 (34.62 %)

9 (8.91 %)

0.0097*

0.35

0.0008*

0.003

Tenofovir

6 (5.94 %)

0

7 (6.93 %)

   

0.39

Diabetes

16 (15.84 %)

3 (11.54 %)

30 (29.70 %)

0.58

0.02*

0.06

0.02

Hypertension

32 (31.68 %)

10 (38.46 %)

49 (48.51 %)

0.51

0.01*

0.36

0.05

Malignancy

5 (4.95 %)

2 (7.69 %)

9 (8.91 %)

   

0.54

CKD

5 (4.95 %)

0

7 (6.93 %)

   

0.36

HIV

22 (21.78 %)

1 (3.85 %)

27 (26.73 %)

0.03*

0.41

0.01*

0.04

Indication for antibiotics

       

Pneumonia

15 (14.85 %)

1 (3.85 %)

28 (27.72 %)

0.1899

0.03*

0.0097*

0.0072

bacteremia

5 (4.95 %)

0

2 (1.98 %)

   

0.46

SSTI

40 (39.60 %)

4 (15.38 %)

32 (31.68 %)

   

0.06

Abdominal

1 (0.99 %)

15 (57.69 %)

4 (3.96 %)

<0.0001*

0.37

<0.0001*

<0.0001

CNS

2 (1.98 %)

0

0

   

0.61

UTI

3 (2.97 %)

5 (19.23 %)

1 (0.99 %)

0.0091*

0.62

0.0013*

0.0003

Bone or joint infection

25 (24.75 %)

0

16 (15.84 %)

0.0046*

0.11

0.04*

0.01

Sepsis of unknown etiology

10 (10.20 %)

1 (4.55 %)

15 (15.00 %)

   

0.31

  1. P < 0.05 between individual groups denoted by italics and asterisk
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BMC Research Notes

ISSN: 1756-0500

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