Genital infections and risk of premature rupture of membranes in Mulago Hospital, Uganda: a case control study

BMC Research Notes

Table 2 Bivariate analysis for genital symptoms and infections among cases (had PROM) and controls (without PROM)

Variable	Cases N = 87 (100 %)	Controls N = 87 (100 %)	P value	OR (95 % CI)
Abnormal vaginal discharge
Yes	47 (54.0)	32 (36.8)	0.023	2.02 (1.10–3.70)
No	40 (46.0)	55 (63.2)
Painful genital ulcer history
Yes	9 (10.3)	3 (3.4)	0.087	3.23 (0.84–12.37)
No	78 (89.7)	84 (56.6)
HSV-2 serology
Positive	49 (56.0)	46 (53.0)	0.648	1.15 (0.63–2.09)
Negative	38 (44.0)	41 (56.6)
HSV-2 ELISA optical densities
>3.4 (high positives)	32 (37.0)	19 (22.0)	0.032	2.08 (1.07–4.07)
≤3.4 (negative or low positive)	55 (63.0)	68 (78.0)
HIV status
Positive	12 (13.8)	12 (13.8)	0.098	0.99 (0.42–2.34)
Negative	75 (86.2)	75 (86.2)
Candida
Positive	18 (20.7)	43 (49.4)	<0.001	0.27 (0.14–0.52)
Negative	69 (79.3)	44 (50.6)
Trichomonas vaginalis
Positive	18 (20.7)	7 (8.0)	0.02	2.98 (1.18–7.56)
Negative	69 (79.3)	80 (92.0)
Bacterial vaginosis
Positive	0 (0.0)	2 (2.3)	^a
Negative	87 (100.0)	85 (97.7)
Neisseria gonococcus
Positive	0 (0.0)	1 (1.1)	^a
Negative	87 (100.0)	86 (98.9)
Chlamydia trachomatis
Positive	4 (4.6)	2 (2.3)	0.415	2.05 (0.37–11.49)
Negative	83 (95.4)	85 (97.7)
Syphilis
Positive	0 (0.0)	0 (0.0)	^a
Negative	100 (100.0)	100 (100.0)

We assessed the association between PROM and: abnormal vaginal discharge, history of painful genital ulcer, candidiasis, Trichomonas vaginalis, preterm labour, HSV-2 serostatus, HSV-2 titres, HIV, bacterial vaginosis, Neisseria gonorrhoea, Group B streptococcus and with syphilis. The italicized odds ratios had a significant association with PROM (abnormal vaginal discharge, candidiasis, Trichomonas vaginalis, and preterm labour and HSV-2 titres)
^aMeans no further analysis was done for these variables due to few numbers

ISSN: 1756-0500