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Table 1 Characteristics of subjects diagnosed with primary HIV-associated thrombocytopenia in the US Military Natural History Study 1986–2013

From: Impact of the highly active antiretroviral therapy era on the epidemiology of primary HIV-associated thrombocytopenia

 

Pre-HAART era

1986–1995

Early HAART era

1996–2001

Later HAART era

2002–2013

P value

No. of cases

151

37

30

 

Median age (yrs) (IQR)

32 (27, 38)

34 (31, 39)

36 (29, 41)

NS

Male gender

138 (91.4 %)

36 (97.3 %)

30 (93.3 %)

NS

Race

   

NS

 Caucasian

87 (57.6 %)

25 (67.6 %)

17 (56.7 %)

 

 African–American

52 (34.4 %)

9 (24.3 %)

10 (33.3 %)

 

 Hispanic

10 (6.6 %)

2 (5.4 %)

2 (6.7 %)

 

 Other

2 (1.4 %)

1 (2.7 %)

1 (3.3 %)

 

Nadir platelet count

 <50 × 109/l

73 (48.3 %)

11 (29.7 %)

6 (20.0 %)

0.005

 <20 × 109/l

33 (21.8 %)

6 (16.2 %)

4 (13.3 %)

NS

CD4 count (cells/μl)

 ≤100

59 (39.1 %)

9 (24.3 %)

2 (6.7 %)

 

 101–200

20 (13.2 %)

6 (16.2 %)

1 (3.3 %)

 

 201–350

26 (17.2 %)

11 (29.7 %)

10 (33.3 %)

 

 351–500

19 (12.6 %)

4 (10.8 %)

8 (26.7 %)

 

 >500

26 (17.2 %)

6 (16.2 %)

9 (30.0 %)

 

 Not determined

1 (0.7 %)

1 (2.7 %)

  

 Median (IQR)

156 (30, 406)

262 (148, 378)

380 (255, 517)

<0.001

  1. HAART highly active antiretroviral therapy, IQR interquartile range