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Table 2 Demographics, clinical staging, treatments, PLK1 mRNA and FOXM1 mRNA expression of the patients in each tissue group

From: FOXM1 and polo-like kinase 1 are co-ordinately overexpressed in patients with gastric adenocarcinomas

 

Gastric normal

Gastric adenocarcinoma

Number of cases

13

8 (1HGD)

Male

4 (31)

7 (88) (p = 0.02)

Age

72 ± 3

70 ± 4 (p = 0.45)

Smoking

 Never

1 (8)

1 (11) (p = 0.45)

 Ex-smoker

1 (8)

2 (22) (p = 0.98)

 Current

5 (38)

6 (67) (p = 0.09)

 Missing

6 (46)

0

Pathological differentiation

 Poor

 

6 (75)

 Moderate

 

0

 Well

 

0

 Missing

 

2 (25)

Depth of invasion

 T1

 

1 (13)

 T2

 

2 (25)

 T3

 

3 (50)

 T4

 

0

Missing

 

1 (13)

Metastatic disease

 Local (N)

 

3 (37.5)

 Distant (M)

 

0 (0)

AJCC 2010 Stage

 1

 

2 (25)

 2

 

3 (36)

 3

 

2 (25)

 4

 

0

 Missing

 

1 (13)

Treatment

 Surgery

 

6 (75)

 Surgery and chemotherapy

 

1 (13)

 Chemotherapy

 

0

 Chemo-radiotherapy

 

0

 EMR

 

0

 Palliative care

 

1 (13)

 Missing

 

0

PLK1 mRNA expression

 mRNA level ×10

2.1

18.8

 Positive expression

2 (15)

5 (63) (p = 0.056)

FOXM1 mRNA expression

 mRNA level ×10

1.2

9.2

 Positive expression

0 (0)

6 (75) (p = 0.001)

  1. The number of cases is shown in each category, percentages are in brackets. mRNA levels are mean expression levels and standard deviation relative to 18S ribosomal RNA and standards derived from HET1a cell lines. The number of patients with clinical data missing is indicated. Positive expression is defined as an expression level equal or higher to the mean of the normal sample plus two standard deviations about the mean for the indicated gene. P values calculated by Chi2 test are indicated
  2. HGD high grade dysplasia, EMR endoscopic mucosal resection