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Fig. 3 | BMC Research Notes

Fig. 3

From: Focused molecular analysis of small cell lung cancer: feasibility in routine clinical practice

Fig. 3

Proposed model for molecular analysis of SCLC and incorporation into translational studies. Patients should undergo a tumour biopsy to obtain sufficient tissue for molecular analysis alongside collection of blood specimens to isolate circulating plasma DNA (cpDNA) and circulating tumour cells (CTCs). Molecular analysis of these samples should be used for translational studies. These may be clinical studies in which patients identified to have actionable aberrations enter clinical studies in which there treatment (T) is determined by sequencing data. These patients should have sequential genomic analysis through cpDNA and CTCs to identify further molecular aberrations (X) that may confer resistance and determine further treatment (A, B, C and D) strategies. These molecular studies are also likely to identify novel or non-actionable changes within SCLC that should be further studied to determine their functional role and potential as novel therapeutic targets for the treatment of SCLC

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