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Table 2 Eighteen subsequent malignancies occurred in PPBL patients

From: Persistent polyclonal binucleated B-cell lymphocytosis and MECOM gene amplification

Patients

Delay between PPBL and subsequent malignancy’s diagnosis

Type of malignancy

Follow-up

UPN36

38 months

DLBCL

56 months

UPN47

20 months

SMZL

+65 months

UPN57

92 months

DLBCL

99 months

UPN63

Diagnosis of PPBL and lymphoma was concomitant

DLBCL

+13 months

UPN71

77 months

SMZL

+86 months

UPN83

120 months

DLBCL

+131 months

UPN1

264 months

MGUS

+348 months

UPN10

144 months

MGUS

+148 months

UPN157

44 months

MGUS

+47 months

UPN118

Diagnosis of PPBL and MGUS was concomitant

MGUS

+36 months

UPN163

Diagnosis of PPBL and MGUS was concomitant

MGUS

+57 months

UPN105

Diagnosis of PPBL and MGUS was concomitant

MGUS

+42 months

UPN5

96 months

Mammary carcinoma

+272 months

UPN6

3 months

Pulmonary carcinoma

3 months

UPN70

22 months

Pulmonary carcinoma

+22 months

UPN86

132 months

Pulmonary carcinoma

+146 months

UPN160

114 months

Pulmonary carcinoma

112 months

UPN67

156 months

Cervical carcinoma

+181 months

  1. Six patients developed solid tumors (4 pulmonary cancers, 1 breast cancer and 1 cervical carcinoma) and 6 patients hematological malignancies (diffuse large B-cell lymphoma (DLBCL) in 4 cases, splenic marginal zone lymphoma (SMZL) in 2 cases) and 6 patients monoclonal gammopathies of undetermined significance (MGUS) (IgM)