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Table 4 Repartition of CNAs observed in CD19 and CD19+ cells. CD19+ cells presented twice as many CNAs as CD19 [83 CNAs (12–218) versus 42 (3–184)]

From: Persistent polyclonal binucleated B-cell lymphocytosis and MECOM gene amplification

CD19−

CNAs—Total (gains/losses)

Chromosome

UPN73

UPN71

UPN57

UPN136

UPN138

UPN99

UPN147

UPN105

Mean

1

2 (2/0)

0 (0/0)

4 (1/3)

1 (0/1)

3 (3/0)

1 (0/1)

0 (0/0)

17 (0/17)

3.5 (0.7/2.8)

2

3 (1/2)

1 (1/0)

0 (0/0)

2 (0/2)

2 (2/0)

0 (0/0)

0 (0/0)

24 (0/24)

4.0 (0.5/3.5)

3

2 (1/1)

0 (0/0)

3 (3/0)

0 (0/0)

0 (0/0)

0 (0/0)

0 (0/0)

8 (1/7)

1.6 (0.6/1.0)

3p

0 (0/0)

0 (0/0)

0 (0/0)

0 (0/0)

0 (0/0)

0 (0/0)

0 (0/0)

0 (0/0)

0.0 (0.0/0.0)

3q

2 (1/1)

0 (0/0)

3 (3/0)

0 (0/0)

0 (0/0)

0 (0/0)

0 (0/0)

8 (1/7)

1.6 (0.6/1.0)

4

0 (0/0)

0 (0/0)

0 (0/0)

2 (1/1)

0 (0/0)

0 (0/0)

1 (1/0)

30 (1/29)

4.1 (0.4/3.7)

5

0 (0/0)

1 (0/1)

1 (0/1)

0 (0/0)

1 (1/0)

0 (0/0)

0 (0/0)

15 (0/15)

2.3 (0.1/2.2)

6

0 (0/0)

0 (0/0)

0 (0/0)

0 (0/0)

1 (1/0)

0 (0/0)

0 (0/0)

11 (0/11)

1.5 (0.1/1.4)

7

0 (0/0)

0 (0/0)

0 (0/0)

0 (0/0)

1 (1/0)

0 (0/0)

1 (1/0)

12 (0/12)

1.8 (0.3/1.5)

8

1 (0/1)

0 (0/0)

0 (0/0)

1 (1/0)

3 (3/0)

0 (0/0)

0 (0/0)

6 (0/6)

1.4 (0.5/0.9)

9

0 (0/0)

4 (0/4)

3 (0/3)

0 (0/0)

4 (2/2)

1 (1/0)

0 (0/0)

7 (0/7)

2.4 (0.4/2.0)

10

1 (1/0)

1 (0/1)

1 (0/1)

0 (0/0)

1 (1/0)

0 (0/0)

1 (1/0)

7 (0/7)

1.5 (0.4/1.1)

11

0 (0/0)

2 (1/1)

0 (0/0)

0 (0/0)

2 (2/0)

0 (0/0)

1 (0/1)

10 (0/10)

1.9 (0.4/1.5)

12

2 (2/0)

0 (0/0)

1 (0/1)

0 (0/0)

1 (1/0)

0 (0/0)

0 (0/0)

8 (1/7)

1.5 (0.5/1.0)

13

0 (0/0)

0 (0/0)

2 (0/2)

0 (0/0)

1 (0/1)

0 (0/0)

0 (0/0)

8 (1/7)

1.4 (0.1/1.3)

14

0 (0/0)

0 (0/0)

0 (0/0)

0 (0/0)

0 (0/0)

0 (0/0)

0 (0/0)

6 (1/5)

0.8 (0.1/0.7)

15

2 (2/0)

1 (1/0)

1 (0/1)

2 (0/2)

2 (1/1)

0 (0/0)

1 (1/0)

4 (1/3)

1.6 (0.9/0.7)

16

1 (1/0)

0 (0/0)

0 (0/0)

1 (1/0)

3 (1/2)

0 (0/0)

0 (0/0)

1 (0/1)

0.8 (0.4/0.4)

17

0 (0/0)

0 (0/0)

1 (0/1)

0 (0/0)

1 (1/0)

0 (0/0)

0 (0/0)

4 (2/2)

0.8 (0.4/0.4)

18

0 (0/0)

0 (0/0)

0 (0/0)

0 (0/0)

1 (1/0)

0 (0/0)

0 (0/0)

1 (0/1)

0.2 (0.2/0.1)

19

0 (0/0)

1 (0/1)

0 (0/0)

0 (0/0)

0 (0/0)

1 (0/1)

1 (0/1)

1 (0/1)

0.5 (0.0/0.5)

20

1 (1/0)

0 (0/0)

0 (0/0)

0 (0/0)

1 (1/0)

0 (0/0)

0 (0/0)

0 (0/0)

0.3 (0.3/0.0)

21

1 (0/1)

1 (0/1)

1 (0/1)

0 (0/0)

0 (0/0)

0 (0/0)

0 (0/0)

1 (0/1)

0.5 (0.0/0.5)

22

0 (0/0)

0 (0/0)

0 (0/0)

0 (0/0)

0 (0/0)

0 (0/0)

1 (1/0)

1 (1/0)

0.3 (0.3/0.0)

X

1 (1/0)

7 (6/1)

13 (13/0)

1 (0/1)

25 (24/1)

0 (0/0)

2 (1/1)

1 (0/1)

6.2 (5.6/0.6)

Y

1 (1/0)

1 (1/0)

2 (0/2)

0 (0/0)

2 (2/0)

0 (0/0)

0 (0/0)

1 (0/1)

0.9 (0.5/0.4)

Total

18 (13/5)

20 (10/10)

33 (18/15)

10 (3/7)

55 (48/7)

3 (1/2)

9 (6/3)

184 (9/175)

41.5 (13.5/28)

CD19+

CNAs—total (gains/losses)

Chromosome

UPN73

UPN8

UPN57

UPN136

UPN127

UPN138

UPN99

UPN147

UPN105

Mean

1

20 (19/1)

0 (0/0)

0 (0/0)

4 (0/4)

0 (0/0)

0 (0/0)

5 (4/1)

8 (1/7)

0 (0/0)

5.0 (3.6/1.4)

2

22 (22/0)

2 (1/1)

0 (0/0)

2 (0/2)

0 (0/0)

1 (0/1)

3 (3/0)

12 (1/11)

0 (0/0)

5.7 (3.9/1.8)

3

20 (19/1)

4 (4/0)

26 (25/1)

0 (0/0)

46 (46/0)

1 (1/0)

2 (2/0)

5 (0/5)

113 (113/0)

25.0 (24.2/0.8)

3p

11 (11/0)

0 (0/0)

1 (0/1)

0 (0/0)

0 (0/0)

0 (0/0)

0 (0/0)

0 (0/0)

0 (0/0)

1.8 (1.7/0.1)

3q

9 (8/1)

4 (4/0)

25 (25/0)

0 (0/0)

46 (46/0)

1 (1/0)

2 (2/0)

5 (0/5)

113 (113/0)

23.2 (22.6/0.7)

4

9 (9/0)

0 (0/0)

2 (0/2)

5 (1/4)

0 (0/0)

1 (1/0)

0 (0/0)

10 (1/9)

0 (0/0)

4.0 (2.3/1.7)

5

14 (13/1)

0 (0/0)

0 (0/0)

2 (0/2)

0 (0/0)

0 (0/0)

0 (0/0)

5 (0/5)

1 (0/1)

3.4 (2.4/1.0)

6

10 (10/0)

1 (1/0)

0 (0/0)

1 (0/1)

0 (0/0)

1 (1/0)

1 (1/0)

5 (1/4)

0 (0/0)

2.9 (2.3/0.6)

7

12 (12/0)

1 (0/1)

0 (0/0)

1 (0/1)

1 (0/1)

0 (0/0)

1 (1/0)

6 (1/5)

0 (0/0)

2.4 (1.6/0.8)

8

13 (11/2)

0 (0/0)

0 (0/0)

0 (0/0)

0 (0/0)

1 (0/1)

1 (1/0)

2 (0/2)

0 (0/0)

2.3 (1.8/0.5)

9

14 (14/0)

0 (0/0)

0 (0/0)

4 (0/4)

0 (0/0)

5 (0/5)

1 (1/0)

4 (1/3)

0 (0/0)

3.8 (2.4/1.4)

10

8 (8/0)

0 (0/0)

0 (0/0)

3 (0/3)

0 (0/0)

0 (0/0)

0 (0/0)

0 (0/0)

0 (0/0)

1.6 (1.2/0.4)

11

9 (9/0)

0 (0/0)

0 (0/0)

2 (0/2)

0 (0/0)

0 (0/0)

1 (1/0)

7 (0/7)

0 (0/0)

2.8 (1.8/1.0)

12

5 (5/0)

1 (0/1)

2 (0/2)

0 (0/0)

1 (1/0)

0 (0/0)

1 (1/0)

8 (1/7)

0 (0/0)

2.7 (1.6/1.1)

13

4 (4/0)

0 (0/0)

1 (0/1)

2 (0/2)

0 (0/0)

1 (0/1)

0 (0/0)

2 (0/2)

1 (1/0)

1.3 (0.7/0.6)

14

3 (3/0)

0 (0/0)

1 (0/1)

0 (0/0)

0 (0/0)

0 (0/0)

2 (2/0)

0 (0/0)

0 (0/0)

1.1 (1.0/0.1)

15

5 (5/0)

0 (0/0)

1 (1/0)

1 (0/1)

2 (0/2)

1 (0/1)

0 (0/0)

2 (1/1)

1 (1/0)

1.8 (1.2/0.6)

16

2 (2/0)

0 (0/0)

0 (0/0)

2 (0/2)

1 (1/0)

2 (0/2)

0 (0/0)

1 (1/0)

1 (0/1)

1.6 (1.0/0.6)

17

4 (4/0)

0 (0/0)

0 (0/0)

1 (0/1)

1 (1/0)

0 (0/0)

0 (0/0)

1 (1/0)

0 (0/0)

0.9 (0.8/0.1)

18

5 (5/0)

1 (1/0)

0 (0/0)

0 (0/0)

0 (0/0)

3 (3/0)

1 (1/0)

1 (0/1)

0 (0/0)

1.9 (1.8/0.1)

19

1 (1/0)

0 (0/0)

0 (0/0)

0 (0/0)

1 (0/1)

0 (0/0)

0 (0/0)

1 (0/1)

0 (0/0)

0.4 (0.2/0.2)

20

5 (5/0)

0 (0/0)

0 (0/0)

0 (0/0)

0 (0/0)

0 (0/0)

2 (2/0)

1 (1/0)

0 (0/0)

1.2 (1.2/0.0)

21

1 (0/1)

0 (0/0)

0 (0/0)

1 (0/1)

0 (0/0)

1 (0/1)

0 (0/0)

2 (0/2)

0 (0/0)

0.6 (0.0/0.6)

22

0 (0/0)

0 (0/0)

0 (0/0)

0 (0/0)

0 (0/0)

0 (0/0)

0 (0/0)

1 (1/0)

0 (0/0)

0.3 (0.3/0.0)

X

28 (27/1)

1 (0/1)

1 (1/0)

7 (5/2)

2 (2/0)

5 (4/1)

1 (1/0)

5 (3/2)

0 (0/0)

7.0 (6.2/0.2)

Y

4 (4/0)

1 (1/0)

0 (0/0)

6 (6/0)

0 (0/0)

14 (14/0)

2 (2/0)

0 (0/0)

0 (0/0)

3.0 (3.0/0.0)

Total

218 (211/7)

12 (8/4)

34 (27/7)

44 (12/32)

55 (51/4)

37 (24/13)

24 (23/1)

89 (15/74)

117 (115/2)

82.7 (66.6/16.1)

  1. 28 % of CNAs (0–97 %) were located on 3q in CD19+ cells compared to 5 % (0–11 %) in CD19 cells (data not shown)