From: Persistent polyclonal binucleated B-cell lymphocytosis and MECOM gene amplification
CD19− | CNAs—Total (gains/losses) | ||||||||
---|---|---|---|---|---|---|---|---|---|
Chromosome | UPN73 | UPN71 | UPN57 | UPN136 | UPN138 | UPN99 | UPN147 | UPN105 | Mean |
1 | 2 (2/0) | 0 (0/0) | 4 (1/3) | 1 (0/1) | 3 (3/0) | 1 (0/1) | 0 (0/0) | 17 (0/17) | 3.5 (0.7/2.8) |
2 | 3 (1/2) | 1 (1/0) | 0 (0/0) | 2 (0/2) | 2 (2/0) | 0 (0/0) | 0 (0/0) | 24 (0/24) | 4.0 (0.5/3.5) |
3 | 2 (1/1) | 0 (0/0) | 3 (3/0) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 8 (1/7) | 1.6 (0.6/1.0) |
3p | 0 (0/0) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 0.0 (0.0/0.0) |
3q | 2 (1/1) | 0 (0/0) | 3 (3/0) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 8 (1/7) | 1.6 (0.6/1.0) |
4 | 0 (0/0) | 0 (0/0) | 0 (0/0) | 2 (1/1) | 0 (0/0) | 0 (0/0) | 1 (1/0) | 30 (1/29) | 4.1 (0.4/3.7) |
5 | 0 (0/0) | 1 (0/1) | 1 (0/1) | 0 (0/0) | 1 (1/0) | 0 (0/0) | 0 (0/0) | 15 (0/15) | 2.3 (0.1/2.2) |
6 | 0 (0/0) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 1 (1/0) | 0 (0/0) | 0 (0/0) | 11 (0/11) | 1.5 (0.1/1.4) |
7 | 0 (0/0) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 1 (1/0) | 0 (0/0) | 1 (1/0) | 12 (0/12) | 1.8 (0.3/1.5) |
8 | 1 (0/1) | 0 (0/0) | 0 (0/0) | 1 (1/0) | 3 (3/0) | 0 (0/0) | 0 (0/0) | 6 (0/6) | 1.4 (0.5/0.9) |
9 | 0 (0/0) | 4 (0/4) | 3 (0/3) | 0 (0/0) | 4 (2/2) | 1 (1/0) | 0 (0/0) | 7 (0/7) | 2.4 (0.4/2.0) |
10 | 1 (1/0) | 1 (0/1) | 1 (0/1) | 0 (0/0) | 1 (1/0) | 0 (0/0) | 1 (1/0) | 7 (0/7) | 1.5 (0.4/1.1) |
11 | 0 (0/0) | 2 (1/1) | 0 (0/0) | 0 (0/0) | 2 (2/0) | 0 (0/0) | 1 (0/1) | 10 (0/10) | 1.9 (0.4/1.5) |
12 | 2 (2/0) | 0 (0/0) | 1 (0/1) | 0 (0/0) | 1 (1/0) | 0 (0/0) | 0 (0/0) | 8 (1/7) | 1.5 (0.5/1.0) |
13 | 0 (0/0) | 0 (0/0) | 2 (0/2) | 0 (0/0) | 1 (0/1) | 0 (0/0) | 0 (0/0) | 8 (1/7) | 1.4 (0.1/1.3) |
14 | 0 (0/0) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 6 (1/5) | 0.8 (0.1/0.7) |
15 | 2 (2/0) | 1 (1/0) | 1 (0/1) | 2 (0/2) | 2 (1/1) | 0 (0/0) | 1 (1/0) | 4 (1/3) | 1.6 (0.9/0.7) |
16 | 1 (1/0) | 0 (0/0) | 0 (0/0) | 1 (1/0) | 3 (1/2) | 0 (0/0) | 0 (0/0) | 1 (0/1) | 0.8 (0.4/0.4) |
17 | 0 (0/0) | 0 (0/0) | 1 (0/1) | 0 (0/0) | 1 (1/0) | 0 (0/0) | 0 (0/0) | 4 (2/2) | 0.8 (0.4/0.4) |
18 | 0 (0/0) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 1 (1/0) | 0 (0/0) | 0 (0/0) | 1 (0/1) | 0.2 (0.2/0.1) |
19 | 0 (0/0) | 1 (0/1) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 1 (0/1) | 1 (0/1) | 1 (0/1) | 0.5 (0.0/0.5) |
20 | 1 (1/0) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 1 (1/0) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 0.3 (0.3/0.0) |
21 | 1 (0/1) | 1 (0/1) | 1 (0/1) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 1 (0/1) | 0.5 (0.0/0.5) |
22 | 0 (0/0) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 1 (1/0) | 1 (1/0) | 0.3 (0.3/0.0) |
X | 1 (1/0) | 7 (6/1) | 13 (13/0) | 1 (0/1) | 25 (24/1) | 0 (0/0) | 2 (1/1) | 1 (0/1) | 6.2 (5.6/0.6) |
Y | 1 (1/0) | 1 (1/0) | 2 (0/2) | 0 (0/0) | 2 (2/0) | 0 (0/0) | 0 (0/0) | 1 (0/1) | 0.9 (0.5/0.4) |
Total | 18 (13/5) | 20 (10/10) | 33 (18/15) | 10 (3/7) | 55 (48/7) | 3 (1/2) | 9 (6/3) | 184 (9/175) | 41.5 (13.5/28) |
CD19+ | CNAs—total (gains/losses) | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Chromosome | UPN73 | UPN8 | UPN57 | UPN136 | UPN127 | UPN138 | UPN99 | UPN147 | UPN105 | Mean |
1 | 20 (19/1) | 0 (0/0) | 0 (0/0) | 4 (0/4) | 0 (0/0) | 0 (0/0) | 5 (4/1) | 8 (1/7) | 0 (0/0) | 5.0 (3.6/1.4) |
2 | 22 (22/0) | 2 (1/1) | 0 (0/0) | 2 (0/2) | 0 (0/0) | 1 (0/1) | 3 (3/0) | 12 (1/11) | 0 (0/0) | 5.7 (3.9/1.8) |
3 | 20 (19/1) | 4 (4/0) | 26 (25/1) | 0 (0/0) | 46 (46/0) | 1 (1/0) | 2 (2/0) | 5 (0/5) | 113 (113/0) | 25.0 (24.2/0.8) |
3p | 11 (11/0) | 0 (0/0) | 1 (0/1) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 1.8 (1.7/0.1) |
3q | 9 (8/1) | 4 (4/0) | 25 (25/0) | 0 (0/0) | 46 (46/0) | 1 (1/0) | 2 (2/0) | 5 (0/5) | 113 (113/0) | 23.2 (22.6/0.7) |
4 | 9 (9/0) | 0 (0/0) | 2 (0/2) | 5 (1/4) | 0 (0/0) | 1 (1/0) | 0 (0/0) | 10 (1/9) | 0 (0/0) | 4.0 (2.3/1.7) |
5 | 14 (13/1) | 0 (0/0) | 0 (0/0) | 2 (0/2) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 5 (0/5) | 1 (0/1) | 3.4 (2.4/1.0) |
6 | 10 (10/0) | 1 (1/0) | 0 (0/0) | 1 (0/1) | 0 (0/0) | 1 (1/0) | 1 (1/0) | 5 (1/4) | 0 (0/0) | 2.9 (2.3/0.6) |
7 | 12 (12/0) | 1 (0/1) | 0 (0/0) | 1 (0/1) | 1 (0/1) | 0 (0/0) | 1 (1/0) | 6 (1/5) | 0 (0/0) | 2.4 (1.6/0.8) |
8 | 13 (11/2) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 1 (0/1) | 1 (1/0) | 2 (0/2) | 0 (0/0) | 2.3 (1.8/0.5) |
9 | 14 (14/0) | 0 (0/0) | 0 (0/0) | 4 (0/4) | 0 (0/0) | 5 (0/5) | 1 (1/0) | 4 (1/3) | 0 (0/0) | 3.8 (2.4/1.4) |
10 | 8 (8/0) | 0 (0/0) | 0 (0/0) | 3 (0/3) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 1.6 (1.2/0.4) |
11 | 9 (9/0) | 0 (0/0) | 0 (0/0) | 2 (0/2) | 0 (0/0) | 0 (0/0) | 1 (1/0) | 7 (0/7) | 0 (0/0) | 2.8 (1.8/1.0) |
12 | 5 (5/0) | 1 (0/1) | 2 (0/2) | 0 (0/0) | 1 (1/0) | 0 (0/0) | 1 (1/0) | 8 (1/7) | 0 (0/0) | 2.7 (1.6/1.1) |
13 | 4 (4/0) | 0 (0/0) | 1 (0/1) | 2 (0/2) | 0 (0/0) | 1 (0/1) | 0 (0/0) | 2 (0/2) | 1 (1/0) | 1.3 (0.7/0.6) |
14 | 3 (3/0) | 0 (0/0) | 1 (0/1) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 2 (2/0) | 0 (0/0) | 0 (0/0) | 1.1 (1.0/0.1) |
15 | 5 (5/0) | 0 (0/0) | 1 (1/0) | 1 (0/1) | 2 (0/2) | 1 (0/1) | 0 (0/0) | 2 (1/1) | 1 (1/0) | 1.8 (1.2/0.6) |
16 | 2 (2/0) | 0 (0/0) | 0 (0/0) | 2 (0/2) | 1 (1/0) | 2 (0/2) | 0 (0/0) | 1 (1/0) | 1 (0/1) | 1.6 (1.0/0.6) |
17 | 4 (4/0) | 0 (0/0) | 0 (0/0) | 1 (0/1) | 1 (1/0) | 0 (0/0) | 0 (0/0) | 1 (1/0) | 0 (0/0) | 0.9 (0.8/0.1) |
18 | 5 (5/0) | 1 (1/0) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 3 (3/0) | 1 (1/0) | 1 (0/1) | 0 (0/0) | 1.9 (1.8/0.1) |
19 | 1 (1/0) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 1 (0/1) | 0 (0/0) | 0 (0/0) | 1 (0/1) | 0 (0/0) | 0.4 (0.2/0.2) |
20 | 5 (5/0) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 2 (2/0) | 1 (1/0) | 0 (0/0) | 1.2 (1.2/0.0) |
21 | 1 (0/1) | 0 (0/0) | 0 (0/0) | 1 (0/1) | 0 (0/0) | 1 (0/1) | 0 (0/0) | 2 (0/2) | 0 (0/0) | 0.6 (0.0/0.6) |
22 | 0 (0/0) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 0 (0/0) | 1 (1/0) | 0 (0/0) | 0.3 (0.3/0.0) |
X | 28 (27/1) | 1 (0/1) | 1 (1/0) | 7 (5/2) | 2 (2/0) | 5 (4/1) | 1 (1/0) | 5 (3/2) | 0 (0/0) | 7.0 (6.2/0.2) |
Y | 4 (4/0) | 1 (1/0) | 0 (0/0) | 6 (6/0) | 0 (0/0) | 14 (14/0) | 2 (2/0) | 0 (0/0) | 0 (0/0) | 3.0 (3.0/0.0) |
Total | 218 (211/7) | 12 (8/4) | 34 (27/7) | 44 (12/32) | 55 (51/4) | 37 (24/13) | 24 (23/1) | 89 (15/74) | 117 (115/2) | 82.7 (66.6/16.1) |