Fig. 4
From: Recurrent mutation in the crystallin alpha A gene associated with inherited paediatric cataract
Haplotype analysis in two families with congenital cataract and the same mutation in Crystallin alpha A (CRYAA) a: CSA110 (reported in this study) and b: CSA91 (previously reported family). Solid circles indicate affected females and solid squares indicate affected males. Only individuals with IDs were available for study. Marker and gene order is D21S1260, CRYAA, D21S1890 and D21S1912 (marker names are indicated on each pedigree). Alleles at each marker are presented as the size of the PCR product detected. Plus sign indicates Crystallin alpha A (CRYAA) mutation carrier. The segregating haplotype is boxed and is the same in both families. A recombination event between D21S1260 and CRYAA was observed in CSA91.05