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Table 4 Cox proportional models for prognostic factors

From: The best objective response of target lesions and the incidence of treatment-related hypertension are associated with the survival of patients with metastatic renal cell carcinoma treated with sunitinib: a Japanese retrospective study

Variables

Progression-free survival

Overall survival

HR

95 % CI

P value

HR

95 % CI

P value

Best objective response on target lesions

 CR/PR

1

  

1

  

 SD

1.67

0.61–4.60

0.23

4.51

0.95–21.4

0.06

 PD

1.88

0.52–6.84

0.09

7.93

1.36–47.8

0.02

 NE

3.56

1.00–12.9

0.05

4.88

1.02–23.2

0.04

Heng risk group

 Favorable

1

  

1

  

 Intermediate

2.70

0.97–7.56

0.06

2.69

0.61–11.9

0.19

 Poor

14.50

4.42–48.0

0.001

10.1

2.03–50.6

0.01

Serum CRP level (mg/dL)

 ≤0.3

1

  

1

  

 0.3<

1.68

0.72–3.96

0.23

1.50

0.58–3.91

0.40

Serum sodium level (mmol/L)

 ≥135

NA

1

  

 135>

1.65

0.63–4.30

0.31

Hypertension related to sunitinib

 Yes

1

  

NA

 No

3.14

1.55–6.36

0.002

  1. HR hazard ratio; CI confience interval; CR complete response; PR pertial response; SD stable disease; PD progressive disease; NE not evaluable; MSKCC Memorial Sloan Kettering Cancer Center; CRP C-reactive protein; NA not analyzed