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Fig. 3 | BMC Research Notes

Fig. 3

From: Effector function of CTLs is increased by irradiated colorectal tumor cells that modulate OX-40L and 4-1BBL and is reversed following dual blockade

Fig. 3

Tumor cells modulate 4-1BBL protein expression after treatment with radiation. a Irradiated (5 and 10 Gy) and non-irradiated (0 Gy) WiDr colorectal carcinoma cells were cultured and subsequently stained with PE-labeled antibody to 4-1BBL. Isotype control staining is shown in gray filled histogram. 4-1BBL-PE positive cells are shown in solid black line histogram. b 4-1BBL expression in five additional colorectal tumor cells lines receiving 10 Gy (black bar) or 0 Gy (gray bar). *P value <0.05. Data graphed are the mean of three (Colo205, HT-29, Caco2) or four (HCT116, SW620) experimental repeats and error bars represent the SEM across the independent experiments

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