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Table 2 Drug interaction between cisplatin and BMS-754807

From: BMS-754807 is cytotoxic to non-small cell lung cancer cells and enhances the effects of platinum chemotherapeutics in the human lung cancer cell line A549

Cell line

Cisplatin (μM)

BMS-754807 (µM)

Interactiona

A549

0.5

0.01

Synergistic

A549

1.0

0.01

Synergistic

A549

2.5

0.01

Synergistic

A549

0.5

0.1

Synergistic

A549

1.0

0.1

Synergistic

A549

2.5

0.1

Synergistic

A549

0.5

0.25

Synergistic

A549

1.0

0.25

Synergistic

A549

2.5

0.25

Synergistic

NCI-H358

2.5

0.001

Antagonistic

NCI-H358

5.0

0.001

Antagonistic

NCI-H358

7.5

0.001

Antagonistic

NCI-H358

2.5

0.1

Additive

NCI-H358

5.0

0.1

Additive

NCI-H358

7.5

0.1

Additive

NCI-H358

2.5

0.25

Antagonistic

NCI-H358

5.0

0.25

Additive

NCI-H358

7.5

0.25

Additive

  1. aCombination index <1 = synergistic interaction, combinations index ~1
  2.  = additive interaction, combination index >1 = antagonistic interaction