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Table 1 CVC infection-related glomerulonephritis in published reports and our patients

From: Central venous catheter infection-related glomerulonephritis under long-term parenteral nutrition: a report of two cases

  Ohara et al. Kusaba et al. Patient 1 Patient 2
Age, sex 13, M 59, F 12, M 24, F
Underlying disease Short bowel syndrome Post-radiation enteritis MMIHS MMIHS
Duration of CVC (years) 13 2 8 18
Blood culture S. epidermidis S. epidermidis S. epidermidis (MSSE) S. epidermidis (MRSE)
24 h CCr/e-GFR (mL/min/1.73 m2) 84.6/− −/5.3 77.4/70.8 −/63.1
C3/C4/CH50 30/8/ <10 30/10/ <12 69/7.4/26.4 57/24/10.5
PR3-ANCA N/D <5 33 19
Renal pathology (positive IF) MPGN C3, IgM, C1 Crescentic GN C3, IgM, IgG MPGN C3, IgM, C1q MPGN C3, IgM
Treatment CVC removal CVC removal CVC removal CVC removal
  Cefazolin for 10 days Cefazolin (3 g/day) for 10 days Cefazolin (3 g/day) for 7 days
   PSL 60 mg/day + MZR 150 mg/day for 10 days MPT 2 courses + PSL 40 mg/day for 1 month
Outcome Full recovery ESRD Full recovery Full recovery
  1. MMIHS megacystis microcolon intestinal hypoperistasis syndrome, CVC central venous catheter, CCr creatinine clearance, e-GFR estimated glomerular filtration rate, GN glomerulonephritis, MPGN membranoproliferative glomerulonephritis, MPT methyl prednisolone pulse therapy, PSL prednisolone, ESRD end stage renal disease