Emergence of a daptomycin-non-susceptible Enterococcus faecium strain that encodes mutations in DNA repair genes after high-dose daptomycin therapy

Table 1 Susceptibility profile of resistance genes of Enterococcus faecium isolates

Isolate	Resistance genes						Minimum inhibitory concentrations (MIC) (μg/ml)/Interpretive criteria^a
Isolate	Aac(6′)-Ii	Ant(6)-Ia	Aph(3′)-III	ErmB	MsrC	TetM	PCG	ABPC	EM	MINO	VCM	TEIC	LVFX	LZD	DAP
EFM01	+	+	+	+	+	+	≥16/R	≥16/R	≥8/R	8/I	1/S	≤2/S	≥8/R	≤2/S	4/S
EFM02	+	+	+	+	+	+	≥16/R	≥16/R	≥8/R	8/I	1/S	≤2/S	≥8/R	≤2/S	256/–

PCG penicillin G, ABPC ampicillin, MINO minocycline, VCM vancomycin, TEIC teicoplanin, LVFX levofloxacin, LZD linezolid, DAP daptomycin, S susceptible, I intermediate, R resistant
^aMIC interpretive criteria, per the clinical and laboratory standards institute (CLSI; M100–S24) [20]

ISSN: 1756-0500