Table 3 Comparison of the clinical and histopathological characteristics between incidental and non-incidental PTMCs
Incidental PTMCs | Non-incidental PTMCs | P value | |
|---|---|---|---|
Number of patients | 274 | 61 | |
Age at diagnosis | 49.1 ± 12.5 (range 16 – 76) years | 47.9 ± 13.1 (range 18–81) years | 0.485 |
Gender | 226F (82.5 %) | 38F (62.3 %) | <0.001 |
48 M (17.5 %) | 23 M (37.7 %) | ||
Hyperthyroidism | 46/228 (20.2 %) | 0/61 (0 %) | <0.001 |
Graves | 21/46 (45.7 %) | 0/0 | – |
Hashimoto | 42/274 (15.3 %) | 5/61 (8.2 %) | 0.147 |
Family History | 4/274 (1.5 %) | 1/61 (1.6 %) | 0.917 |
Singlenodular | 65/274 (23.7 %) | 22/61 (36.1 %) | 0.047 |
Multinodular | 209/274 (76.3 %) | 39/61 (63.9 %) | |
Unifocal | 179/274 (65.3 %) | 36/61 (59 %) | 0.352 |
Multifocal | 95/274 (34.7 %) | 25/61 (40.1 %) | |
< or = 5 mm | 96/179(53.6 %) | 13/36 (36.1 %) | 0.055 |
> 5 mm (of unifocal cases) | 83/179 (46.4 %) | 23/36 (63.9 %) | |
Metastases | 0/274 (0 %) | 0/61 (0 %) | >0.999 |
Capsule involvement | 21/274 (7.7 %) | 47/61 (77 %) | <0.001 |
T > 1 and/or N > 0 | 17/274 (6.2 %) | 19/61 (31.1 %) | <0.001 |
Histological types | 145/274 (52.9 %) CPC | 25/61 (41 %) | 0.091 |
53/274 (19.4 %) EFVC | 8/61 (13.1 %) | 0.254 | |
36/274 (13.1 %) N-EFVC | 22/61 (36 %) | <0.001 | |
37/274 (13.5 %) SVC | 4/61 (6.6 %) | 0.134 | |
3/274 (1.1 %) T-CVC | 2/61 (3.3 %) | 0.203 | |
Total or near total thyroidectomy | 240/274 (87.5 %) | 52/61 (85.2 %) | 0.620 |
131I | 202/274 (73.7 %) | 57/61 (93.4 %) | <0.001 |
Follow up | 10.9 ± 5.4 (range 5–33) years | 9.1 ± 4.3 (range 5–27.5) years | 0.005 |
Recurrence | 2/274 (0.7 %) | 0/61 (0 %) | 0.503 |
Persistence | 8/274 (3 %) | 5/61 (8.2 %) | 0.054 |
Disease free | 264/274 (96.3 %) | 56/61 (91.8 %) | 0.120 |