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Table 3 Pathological characteristics of patients carrying or not BRCA1/2 mutations

From: Clinical and pathological features of BRCA1/2 tumors in a sample of high-risk Moroccan breast cancer patients

Variables

BRCA1/2+

BRCA1/2−

p value

Histological type

 Invasive ductal carcinoma

10 (90.9 %)

27 (93.1 %)

0.63

 Invasive lobular carcinoma

0 (0 %)

1 (3.4 %)

 

 Medullary carcinoma

1 (9.1 %)

1 (3.4 %)

 

Tumor size

 T1–T2

8 (72.7 %)

19 (65.5 %)

1.00

 T3

2 (18.2 %)

(20.7 %)

 

 T4

1 (9.1 %)

4 (13.8 %)

 

SBR grade

 I–II

4 (36.4 %)

23 (79.3 %)

0.02

 III

7 (63.6 %)

6 (20.7 %)

 

Node involvement

 N−

5 (45.5 %)

13 (44.8 %)

1.00

 N+

6 (54.5 %)

16 (55.2 %)

 

Estrogen receptors status

 ER−

7 (63.6 %)

10 (40.0 %)

0.28

 ER+

4 (36.4 %)

15 (60.0 %)

 

Progesterone receptors status

 PR−

7 (63.6 %)

11 (44.0 %)

0.47

 PR+

4 (36.4 %)

14 (56.0 %)

 

Her2/neu

 Her2−

5 (62.5 %)

16 (66.7 %)

1.00

 Her2+

3 (37.5 %)

8 (33.3 %)

 

Triple negative (ER−, PR− and HER2/neu−)

 Yes

5 (62.5 %)

4 (16.7 %)

0.02

 No

3 (37.5 %)

20 (83.3 %)

 
  1. Values in Italic are statistically significant (p value ≤ 0.05)