References | Without exposure-mediator interaction (95Â % confidence interval) | With exposure-mediator interaction (95Â % confidence interval) | Discrepancy found with and without exposure-mediator interaction reason discussed |
---|---|---|---|
Banack et al. [26] | Not reported | Controlled direct effect with CVD Risk ratio: 0.62 (0.49, 0.78) Risk difference: −0.12 (−0.20, −0.04) Controlled direct effect without CVD Risk ratio: 1.30 (1.13, 1.49) Risk difference: 0.03 (0.01, 0.05) Total effect Risk ratio: 1.24 (1.11, 1.39) Risk difference: 0.03 (0.02, 0.05) | Not applicable |
D’Amelio et al. [27] | Effects of treatment on glucose level at 12 months mediated by OC at 6 months: Natural direct effect: −0.033 (−0.186, 0.121) Natural indirect effect: −0.050 (−0.178, 0.078) Total effect: −0.082 (−0.174, 0.009) | Not reported | Not applicable |
Freeman et al. [28] | Anxiety (Boot SE), P value Direct effect: 0.21 (0.16), 0.19 Indirect effect: 0.18 (0.11), 0.09 Total effect: 0.39 (0.16), 0.01 Depression (Boot SE), P value Direct effect: 0.24 (0.14), 0.09 Indirect effect: 0.15 (0.11), 0.18 Total effect: 0.39 (0.16), 0.01 BCSS—negative self (Boot SE), P value Direct effect: 0.33 (0.18), 0.06 Indirect effect: 0.06 (0.08), 0.48 Total effect: 0.39 (0.16), 0.01 BCSS—positive self (Boot SE), P value Direct effect: 0.40 (0.17), 0.02 Indirect effect: −0.01 (0.05), 0.92 Total effect: 0.39 (0.16), 0.01 BCSS—negative other (Boot SE), P value Direct effect: 0.22 (0.16), 0.17 Indirect effect: 0.18 (0.11), 0.13 Total effect: 0.39 (0.16), 0.01 | Not applicable | Not applicable |
Jackson et al. [29] | Stroke Direct effect: 1.13 (1.05,1.22) Indirect effect: 1.005 (1.001,1.011) Total effect: 1.14 (1.06,1.22) | Stroke Direct effect: 1.13 (1.06,1.22) Indirect effect: 1.005 (1.001,1.011) Total effect: 1.14 (1.06,1.22) | No Not applicable |
Kositsawat et al. [30] | Not reported | Not applicable | Not applicable |
Louwies et al. [31] | Systolic blood pressure Direct effect: 2.93 (CIs not reported) Indirect effect: −0.42 (−1.35 to 0.17) Total effect: not reported Diastolic blood pressure Direct effect: 3.15 (CIs not reported) Indirect effect: −0.59 (−1.44 to 0.07) Total effect: not reported | Not applicable | Not applicable |
Lu et al. [32] | Overweight (for metabolic mediators) Blood pressure Natural direct effect: 1.16 (1.09–1.24) Natural indirect effect: 1.06 (1.03–1.08) Total effect: 1.22 (1.14–1.30) Obesity (for metabolic mediators) Blood pressure Natural direct effect: 1.28 (1.15–1.43) Natural indirect effect: 1.13 (1.07–1.19) Total effect: 1.42 (1.25–1.60) | Overweight (for metabolic mediators) Blood pressure Natural direct effect: 1.16 (1.09–1.24) Natural indirect effect: 1.05 (1.02–1.08) Total effect: 1.22 (1.14–1.30) Obesity (for metabolic mediators) Blood pressure Natural direct effect: 1.28 (1.15–1.42) Natural indirect effect: 1.10 (1.03–1.17) Total effect: 1.43 (1.25–1.62) | No Not applicable |
Mendola et al. [33] | Not reported | Peri- or intraventricular hemorrhage: Controlled direct effect: 3.2 (1.4–7.7) Total effect: 2.9 (2.4–3.4) | Not applicable |
Messerlian et al. [34] | Uterine: <35Â weeks Controlled direct effect: 2.43 (0.85, 6.93) Total effect: 2.27 (1.32, 3.89) | Not applicable | Not applicable |
Raghavan et al. [35] | Metabolic syndrome score: Direct effect: not reported Indirect effect: 1.20 (1.07, 1.33) Total effect: not reported | Not applicable | Not applicable |
Rao et al. [36] | Smoking: low vs. high Controlled direct effect: 1.5 (1.4, 1.5) Total effect: 1.6 (1.4, 1.9) | Not applicable | Not applicable |
Song et al. [37] | HOMA-IR: Effect not mediated: 1.32 (0.95, 1.88) Mediated effect: 1.22 (1.02, 1.49) SHBG: Effect not mediated: 1.97 (1.25, 3.10) Mediated effect: 1.16 (1.03, 1.33) E-selectin: Effect not mediated: 1.56 (1.10, 2.21) Mediated effect: 1.12 (1.02, 1.23) Systolic blood pressure: Effect not mediated: 1.61 (1.25, 2.16) Mediated effect: 1.03 (1.01, 1.07) | Not reporteda | Not applicable |
Xie et al. [38] | Not reported | Not applicable | Not applicable |