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Fig. 2 | BMC Research Notes

Fig. 2

From: Complete regression of primary cutaneous malignant melanoma associated with distant lymph node metastasis: a teaching case mimicking blue nevus

Fig. 2

Microscopic examination of the complete regression of primary cutaneous MM. a On low-power view of the surgical cutaneous specimen from the right sole, a hyperpigmented lesion was made up of an aggregation of melanophages with surrounding variably sclerotic fibrosis mainly in the middle to deep layer of dermis (H&E stains). The covering non-disordered epidermis exhibited attenuated and atrophic change with absence of rete ridge. Bar  2 mm. b On high-power view (H&E stains), these aggregated round to oval cells contained bland-looking small nuclei and abundant melanin-pigmented cytoplasm. In addition, immunohistochemically, these melanophages were strongly positive for CD68 (inset). Bar  50 μm. c In these fibrotic dermis, reactive vascular networks were noted, associated with mild interstitial and perivascular lymphocytic infiltrate. Furthermore the peripheral epidermis displayed exocytosis of focal nested lymphocytes (inset). Bar  500 μm. d In immunohistochemistry, dermal infiltrating CD8-positive T-lymphocytes (right) were markedly larger than CD4-positive T-lymphocytes (left) in number in this cutaneous lesion. Bar  1000 μm

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