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Table 1 Confirmed acute OL differentiation hits from the NCC library screen

From: A high throughput drug screening assay to identify compounds that promote oligodendrocyte differentiation using acutely dissociated and purified oligodendrocyte precursor cells

Drug class Compound OL differentiationa EC50, μM
SERM Raloxifene 82 0.1
Toremifene 96 0.1
Tamoxifen 85 0.2
Tricyclic anti-depressants Perphenazine 59 0.1
Fluphenazine 91 0.1
Prochlorperazine 80 0.1
Trifluoperazine 60 0.2
Quetiapine 109 0.4
Non-tricyclic anti-depressants Perospirone 88 0.1
Nitalapram 51 1.1
Escitalopram 84 1.3
Metylperon 64 7.3
Muscarinic Benztropine 66 0.3
Donepezil 142 0.5
Vesamicol 91 1.4
Oxybutynin 67 2.6
Ipatropium 58 8.5
Clemastineb ND 0.2
Adrenergic Salmeterol 52 0.4
Betaxolol 86 4.2
Esmolol 65 240
Ion-channel Ifenprodil 93 0.4
Benproperine 82 0.8
Proxymetacaine 77 1.0
Dofetilide 77 14
DMPP 97 13
Anti-fungal Bifonazole 66 1.7
  1. ND no data. DMPP dimethylphenylpiperazinium
  2. aValues indicate percent positive control
  3. bNot part of the NCC library screen