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Fig. 4 | BMC Research Notes

Fig. 4

From: Identification of reference miRNAs in plasma useful for the study of oestrogen-responsive miRNAs associated with acquired Protein S deficiency in pregnancy

Fig. 4

Normalisation of the relative expression of pregnancy-associated miRNA, miR-141-3p with the miRNA reference panel increases the significance of group differences compared to normalisation with spike-ins alone. a miR-141-3p levels normalised to synthetic spike-ins cel-miR-39 and ath-miR159a alone. b miR-141-3p levels normalised to synthetic spike-ins and endogenous controls miR-188-5p and miR-222-3p. Horizontal bars represent median with interquartile range. Statistical significance determined by one way ANOVA based on the square root transformation of the relative expression levels. Overall significance for differences between the four groups a p = 0.031, b p = 0.0166

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