Table 2 Richness, alpha-diversity, and relative abundance of fecal microbiome in infants with bronchiolitis and healthy controls
Infants with bronchiolitis n = 40 | Healthy control infants n = 115 | P value | |
|---|---|---|---|
Richness, median (IQR) | |||
Number of genera | 17 (13–23) | 13 (10–18) | 0.004 |
Alpha-diversity, median (IQR) shannon index | 2.21 (1.68–2.65) | 1.93 (1.44–2.49) | 0.27 |
Relative abundance of 10 most abundant genera, mean (standard deviation) | |||
Escherichia | 0.21 (0.24) | 0.23 (0.26) | 0.91* |
Bifidobacterium | 0.16 (0.20) | 0.20 (0.21) | 0.49* |
Enterobacter | 0.10 (0.21) | 0.17 (0.24) | 0.27* |
Bacteroides | 0.20 (0.23) | 0.10 (0.19) | 0.10* |
Veillonella | 0.03 (0.09) | 0.06 (0.12) | 0.31* |
Lachnospiraceae incertae sedis | 0.06 (0.10) | 0.04 (0.10) | 0.49* |
Streptococcus | 0.02 (0.09) | 0.03 (0.05) | 0.91* |
Clostridium sensu strictos 1 | 0.01 (0.01) | 0.03 (0.06) | 0.16* |
Enterococcus | 0.01 (0.03) | 0.02 (0.04) | 0.48* |
Akkermansia | 0.02 (0.09) | 0.02 (0.08) | 0.91* |
Microbiome profile, n (%) | 0.01 | ||
Bacteroides-dominant profile | 19 (48) | 24 (21) | |
Bifidobacterium-dominant profile | 6 (15) | 26 (23) | |
Escherichia-dominant profile | 10 (25) | 36 (31) | |
Enterobacter/Veillonella-dominant profile | 5 (12) | 29 (25) | |