Fig. 3

Probes used for in situ assays. a The CAPN5 gene contains 13 exons (brown). The ADNIV associated mutations occur in exon 6 (red). The three probes correspond to three different spots within the CAPN5 gene. The control scramble probe corresponds to the scrambled version of a sequence in exon 4. Probe 1 corresponds to the indicated sequence in exon 8, and Probe 2 corresponds to the indicated sequence in exon 11. b The probes were tested by application to normal tissue (left) and breast cancer tumor tissue (right)