High urinary interleukin-2 in late post-transplant period portends a risk of decline in kidney allograft function: a preliminary study

Table 7 AUC for potential markers of eGFR decline by ≥ 25% during follow-up

Predictive variables	AUC	CI	p-level
eGFR decline by 25% after 1 year of follow-up, N = 5
Proteinuria/Cr	0.817	0.584–1.000	0.028
IL-2/Cr	0.767	0.519–1.000	0.065
Proteinuria/Cr + IL-2/Cr	0.858	0.670–1.000	0.013
eGFR decline by 25% after 2 years of follow-up, N = 7
Proteinuria/Cr	0.779	0.561–0.997	0.028
Time post-transplant	0.705	0.451–0.958	0.108
Proteinuria/Cr + Time post-transplant	0.799	0.597–1.000	0.019

Only variables that significantly influenced the eGFR decline in univariate logistic regression are included
AUC, areas under the receiver operating characteristic curve; CI, 95%-confidence interval; eGFR, estimated glomerular filtration rate; IL-2, interleukin 2; Cr, creatinine; N, number of patients with certain decline in eGFR

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