Fig. 2

Tumor phenotype and survival curve. a Tumor histopathology was determined in Msh2-Msh3 ^+/+ and Msh2-Msh3 ^GD/GD animals. Gastrointestinal tumors in the Msh2-Msh3 ^+/+ animals included an adenoma and the other tumors included a histiocytic sarcoma. The GI tumors in the Msh2-Msh3 ^GD/GD animals included an adenoma, carcinoma and a polypoid adenomadous hyperplasia, the other tumors included two hepatic carcinomas, an extramedullary myeloma, bronchio-alveolar adenoma and two hepatic adenomas. b Tumor microsatellite amplifications show contractions in Msh2-Msh3^GD/GD tumors, no MSI was observed using the D7Mit91 marker in the tumors tested. c Survival curve represents the time of death or the time at which the mice became moribund and were sacrificed. The survival curves were generated using Graphpad prism 3.0 software. The black line, Msh2-Msh3^+/+ mice (n = 20), the grey line represents the Msh2-Msh3^GD/GD (n = 22) animals. The 50% survival was found to be 21 months in the Msh2-Msh3^GD/GD animals, p value > 0.05