Marker | Msh2-Msh3
+/+
| Msh2-Msh3
GD/GD
| Msh2-Msh3
−/−
|
---|
Somatic MSI |
 U12335(A)n
| (5/95) 5% | (16/72) 22% | (1/99) 1% |
 TG27
| (3/90) 3% | (8/95) 8% | (11/75) 15% |
 D7Mit91 | (0/77) 0% | (1/77) 1% | (7/79) 9% |
Tumor MSI |
 U12335 | (0/6) 0% | (4/8) 50% | (2/15) 13% |
 TG27
| (0/6) 0% | (1/8) 13% | (4/8) 50% |
- Somatic and tumor microsatellite instability: MSI was analyzed using the mononucleotide marker U12235n and dinucleotide markers TG27 and D7Mit91 using pooled tail DNA from five each, Msh2-Msh3
+/+
, Msh2-Msh3
−/−
and Msh2-Msh3
GD/GD mice, (p values U12335: Msh3+/+ vs. Msh3GD/GD = 0.036 and Msh3+/+: Msh3−/− = 0.02, p values TG27: Msh3+/+ vs. Msh3GD/GD = 0.06 and Msh3+/+ vs. Msh3−/− = 0.038, p values D7Mit91: Msh3+/+ vs. Msh3−/− = 0.05)