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Table 1 Somatic and tumor MSI

From: An Msh3 ATPase domain mutation has no effect on MMR function

Marker

Msh2-Msh3 +/+

Msh2-Msh3 GD/GD

Msh2-Msh3 −/−

Somatic MSI

 U12335(A)n

(5/95) 5%

(16/72) 22%

(1/99) 1%

 TG27

(3/90) 3%

(8/95) 8%

(11/75) 15%

 D7Mit91

(0/77) 0%

(1/77) 1%

(7/79) 9%

Tumor MSI

 U12335

(0/6) 0%

(4/8) 50%

(2/15) 13%

 TG27

(0/6) 0%

(1/8) 13%

(4/8) 50%

  1. Somatic and tumor microsatellite instability: MSI was analyzed using the mononucleotide marker U12235n and dinucleotide markers TG27 and D7Mit91 using pooled tail DNA from five each, Msh2-Msh3 +/+ , Msh2-Msh3 −/− and Msh2-Msh3 GD/GD mice, (p values U12335: Msh3+/+ vs. Msh3GD/GD = 0.036 and Msh3+/+: Msh3−/− = 0.02, p values TG27: Msh3+/+ vs. Msh3GD/GD = 0.06 and Msh3+/+ vs. Msh3−/− = 0.038, p values D7Mit91: Msh3+/+ vs. Msh3−/− = 0.05)