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Table 4 Effect of chronic treatment with GSG root extract on the absolute and relative organ weights of liver, kidney and spleen of male and female mice as compared to the controls

From: Toxicological investigation of acute and chronic treatment with Gnidia stenophylla Gilg root extract on some blood parameters and histopathology of spleen, liver and kidney in mice

 

Control

Treatment groups (mg/kg body weight)

400

800

Liver

 Absolute weight (in g)

  Male

1.56 ± 0.07

1.48 ± 0.07 (0.630)

1.56 ± 0.14 (0.984)

  Female

1.93 ± 0.02

1.78 ± 0.13 (0.396)

1.82 ± 0.16 (0.564)

 Relative weight (in g/100 g bw)

  Male

3.92 ± 0.32

4.02 ± 0.24 (0.939)

4.25 ± 0.22 (0.575)

  Female

5.04 ± 0.08

4.50 ± 0.16 (0.344)

5.02 ± 0.51 (0.998)

Kidney

 Absolute weight (in g)

  Male

0.26 ± 0.01

0.25 ± 0.01 (0.410)

0.25 ± 0.06 (0.597)

  Female

0.21 ± 0.01

0.19 ± 0.01 (0.444)

0.22 ± 0.02 (0.362)

 Relative weight (in g/100 g bw)

  Male

0.66 ± 0.06

0.69 ± 0.03 (0.900)

0.68 ± 0.04 (0.936)

  Female

0.54 ± 0.02

0.50 ± 0.02 (0.667)

0.62 ± 06 (0.233)

Spleen

 Absolute weight (in g)

  Male

0.14 ± 0.02

0.11 ± 0.01 (0.100)

0.12 ± 0.01 (0.100)

  Female

0.17 ± 0.01

0.16 ± 0.02 (0.639)

0.18 ± 0.02 (0.731)

 Relative weight (in g/100 g bw)

  Male

0.36 ± 0.07

0.30 ± 0.01 (0.390)

0.32 ± 0.01 (0.630)

  Female

0.44 ± 0.03

0.43 ± 0.07 (0.990)

0.49 ± 0.05 (0.755)

  1. Values are given as mean ± S.E.M. n = 10. The figures under parenthesis indicate the calculated P values of the treatment groups as compared to the control. Bw body weight