The transcriptome response of the ruminal methanogen Methanobrevibacter ruminantium strain M1 to the inhibitor lauric acid

Table 1 Number of genes significantly differential expressed within functional categories

Category	Gene count	Treatment vs. control		Control vs. blank		Treatment vs. blank
Category	Gene count	Up	Down	Up	Down	Up	Down
Amino acid metabolism	94	2^b	3	0	4	1	2
Cell cycle	29	1	0	0	0	0	0
Cell envelope	189	28^a	0^b	2	4	2	3
Cellular processes	14	3	1	1	0	2^a	0
Central carbon metabolism	61	2	1	0	1	2	0
Energy metabolism	141	9	9^a	6	3	6	0
Lipid metabolism	21	0	0	1	0	0	3^a
Mobile elements	87	37^a	0	0	37^a	0	0
Nitrogen metabolism	14	0	1	1	0	1	0
Nucleic acid metabolism	60	2	1	0	0	0	0
Protein fate	51	0^b	2	1	0	1	0
Protein synthesis	169	7	1	0^b	9	0^b	0
Purines and pyrimidines	47	2	0	0	0	0	0
Regulation	68	0^b	5^a	5^a	0	2	0
Secondary metabolites	12	4	0	0	0	0	0
Transcription	26	1	0	0	0	0	0
Transporters	97	11	1	7^a	3	7^a	1
Unknown function	183	10	8	4	2^b	3	0
Vitamins and cofactors	142	8	3	2	4	5	1
Total^c	1505	127	36	30	67	32	10

^aSignificant functional enrichment in a Fisher exact test (p < 0.05)
^bSignificant functional underrepresentation in a Fisher exact test (p < 0.05)
^cNon-conserved hypothetical genes and RNAs are omitted in the classification [11]. Treatment: with DMSO-dissolved C₁₂, control: with DMSO alone, blank: without C₁₂ and DMSO

ISSN: 1756-0500