Table 1 Predicted transcription factor binding sites in evolutionarily conserved elements, as identified by genomic evolutionary rate profiling of the sequence located 500 bp upstream of human ICAM-1-related gene transcription start sites
Human sequence | Matrix familya | Matrixa | Description |
|---|---|---|---|
Annotated | V$HIFF | V$ARNT.01 | AhR nuclear translocator homodimers |
V$HIF1.02 | Hypoxia inducible factor | ||
V$CLOCK_BMAL1.01 | Clock/BMAL1, NPAS2/BMAL1 heterodimers | ||
V$HRE.02 | Hypoxia-response elements | ||
V$HRE.03 | Hypoxia response elements, HIF1a/ARNT heterodimers | ||
V$HASF | V$HAS.01 | HIF-1 ancillary sequence | |
V$NRF1 | V$NRF1.01 | Nuclear respiratory factor | |
V$NRF1.02 | Nuclear respiratory factor | ||
V$EBOX | V$MNT.01 | MAX binding protein | |
V$MYCMAX.02 | MYC-MAX binding sites | ||
V$MYCMAX.03 | MYC-MAX binding sites | ||
V$NMYC.01 | N-myc | ||
V$USF.04 | Upstream stimulating factor ½ | ||
V$HESF | V$DEC1.02 | Basic helix-loop-helix protein E40 (BHLHE40) | |
V$HELT.01 | Hey-like transcriptional repressor | ||
V$CREB | V$XBP1.01 | X-box binding protein 1 | |
V$TAXCREB.02 | Tax/CREB complex | ||
V$STAF | V$STAF.01 | Se-Cys tRNA gene transcription activating factor | |
Predicted (based on mouse) | V$XBBF | V$RFX1.02 | X-box binding protein RFX1 |
V$RFX2.02 | Regulatory factor X, 2 | ||
V$RFX3.01 | Regulatory factor X, 3 | ||
V$RFX4.01 | Regulatory factor X, 4 | ||
V$RFX4.03 | Regulatory factor X, 4 | ||
V$RFX5.02 | Regulatory factor X, 5 | ||
V$XBOX.01 | Motif bound by RFX proteins | ||
V$MIF1.01 | Myc Intron-binding protein (MIBP)/RFX complex | ||
V$AP1F | V$AP1.01 | Activator protein 1 | |
V$AP1.02 | Activator protein 1 | ||
V$BATF.01 | Basic leucine zipper TF | ||
V$FOSL1.01 | Fos-like antigen 1 | ||
V$JUNB.01 | Jun-B | ||
V$AP1R | V$BACH2.02 | BTB and CNC homology 1, basic leucine zipper TF 2 | |
V$MARE_ARE.01 | Antioxidant response elements | ||
V$NFE2.01 | NF-E2 p45 |