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Fig. 2 | BMC Research Notes

Fig. 2

From: An increased fraction of circulating miR-363 and miR-16 is particle bound in patients with chronic lymphocytic leukaemia as compared to normal subjects

Fig. 2

MiR-363 levels and clinical outcome. a Mir-363 levels are compared between healthy volunteers (HV) (n = 11), asymptomatic patients enrolled in the CLEAR clinical trial (n = 48) and patients, who met the criteria for treament, enrolled in the ARCTIC clinical trial (n = 95). Mean ± SEM are indicated. There was no significant difference (Mann–Whitney test) between HVs and CLEAR patients but there were significant differences between HVs and ARCTIC (P = 0.0313) patients and between CLEAR and ARCTIC patients (P = 0.0091). b MiR-363 levels of ARCTIC patients with mutated and unmutated immunoglobulin heavy chain genes are compared. Mean ± SEM are indicated. There was no significant difference (Mann–Whitney test) between groups. c MiR-363 levels of ARCTIC patients are compared by gender. Median and interquartile ranges are indicated. There was no significant difference (Mann–Whitney test) between groups. d MiR-363 levels of ARCTIC patients are compared by Binet clinical stage. Binet A indicates progressive stage A disease. Median and interquartile ranges are indicated. There was no significant difference (Mann–Whitney test) between groups. e, f Kaplan–Meier survival curves of ARCTIC patients. Patients were grouped into those with miR-363 levels above the median (black line) and those with levels below the median (grey line). There was no significant difference (Log-Rank (Mantel-Cox) test) in e overall survival or f progression free survival

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