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Fig. 1 | BMC Research Notes

Fig. 1

From: Mutational analysis of two residues in the DYRK homology box of the protein kinase DYRK1A

Fig. 1

Structure of DYRK1A. a Domain structure DYRK1A and DYRK1B. The DH box is localized between the nuclear localization signal (NLS) and the catalytic domain (cat). The circled P (red) indicates the autophosphorylation of the tyrosine (Y) in the activation loop. Non-conserved N- and C-terminal region are shown in grey. b Sequence conservation of the DH box in DYRK1A and DYRK1B. The alignments illustrate that H90 and R102 in human DYRK1B are not conserved in vertebrates. The corresponding positions in DYRK1A are occupied by D138 and K150, which are conserved in evolution. Amino acids deviating from the human DYRK1A or DYRK1B sequences are shaded. The pathogenic variants in DYRK1B and the corresponding substitutions in DYRK1A are shown in red

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