From: Granulomatosis with polyangiitis: a 17 year experience from a tertiary care hospital in Pakistan
Mahr et al. 2013, Europe | Holle et al.[9], Germany | Reinold-Keller et al. [6], Germany | Stone et al. (2002), USA | Shobha et al. (2018), India | Kumar et al. (2015), India | Sharma et al. [24], India | Our study, 2018 | |
---|---|---|---|---|---|---|---|---|
Total no. of patients | 396 | 445 | 155 | 180 | 60 | 45 | 105 | 51 |
Male/female % | 54/46 | 50/50 | 49/51 | 60/40 | 35/25 | 42/58 | 43/57 | 55/45 |
Mean age at diagnosis | 55 | 51 | 48 | 47 | 44 | 46 | 40 | 44 |
Study period | 1995–2003 | 1996–2002 | 1966–1993 | 2000–2003 | 2002–2010 | 2009–2014 | 2005–2016 | 2000–2017 |
Mean duration of follow up, years | 4.75 | 6 | 7 | NA | 4.7 | NA | 3.1 | NA |
c-ANCA/PR-3 positivity (%) | –/79 | 81/80 | 84 | 76/73 | 93 | 62/38 | 82/62 | 51/100 |
p-ANCA/MPO positivity (%) | –/11 | 4 | 3/– | 11/12 | 7 | 11/7 | 9/7 | 11/21 |
Organ involvement (%) | ||||||||
ENT | 84 | 98 | 93 | 90 | 21 | 80 | 79 | 49 |
Joints | NA | 73 | 61 | 81 | 27 | 42 | 44 | 43 |
Lung | 67 | 60 | 55 | 75 | 63 | 49 | 68 | 80 |
Kidney | 77 | 60 | 54 | 68 | 70 | 33 | 31 | 55 |
Eye | 39 | 40 | 40 | 41 | 11 | 31 | 41 | 12 |
Nervous system | 14 | 17 | 11 | 10 | 25 | 10 | 19 | 18 |
Skin | 30 | 26 | 21 | 39 | 48 | 9 | 30 | 16 |
Heart | 10 | 11 | 13 | 4 | 1 | 7 | 6 | NA |
GIT | 7 | 3 | 3 | 7 | NA | 9 | 12 | NA |
Relapses,% | 47 | 50 | 64 | NA | 13 | 53 | 31 | 18 |
Expired,% | 14 | 10 | 14 | NA | 18 | NA | 17 | 18 |