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Table 1 Summary of age-period-cohort analysis for pleural mesothelioma incidence in four selected gender/age groups

From: Longevity and pleural mesothelioma: age-period-cohort analysis of incidence data from the Surveillance, Epidemiology, and End Results (SEER) Program, 1973–2013

APC parameters Males, age 0–74 Males, age 75+ Females, age 0–74 Females, age 75+
Period effect: peak PM
 Incidence years 1978–1982 2008–2012 1973–1977 2008–2012
 Net drift (95% CI) − 1.8% (− 2.3%, − 1 3%) +4.0% (3.2%, 4.7%) − 1.5% (− 3.3%, 0.3%) +3.7% (1.7%, 5.7%)
 p value < 0.0001 < 0.0001 0.11 0.0002
 Period RRs different from 1988 to 1992? Yes Yes No Yes
 p value < 0.0001 < 0.0001 0.67 0.02
 Period deviation is non-linear? Yes Yes No No
 p value 0.03 0.05 0.89 0.81
Cohort effect: peak PM
 Birth cohort years 1928–1932 1928–1932 1931–1935 1921–1925
 Local drifts = net drift for all age groups? No No No Yes
 p value < 0.0001 0.0002 0.02 0.58
 Cohort RRs different from referent cohort? Yes Yes No Yes
 p value < 0.0001 < 0.0001 0.16 0.01
 Cohort deviation is nonlinear? Yes Yes No No
 p value <0.0001 <0.0001 0.16 0.91
Cross-sectional age trend (95% CI) 12.5% (11.8, 13.2%) 2.2% (0.9, 3.5%) 7.2% (5.9, 8.4%) − 0.1% (− 4.1, 3.9%)
Longitudinal age trend (95% CI) 10.7% (9.9, 11.4%) − 1.7% (− 3.1, − 0.4%) 8.7% (6.7, 10.6%) − 3.7% (− 7.8, 0.4%)
Longitudinal vs. cross-sectional RR trend Negative Positive Negative Positive/flat
Age deviation is non-linear? No Yes No No
p value 0.41 0.0002 0.46 0.07