Actual value | Changes | ||||||
---|---|---|---|---|---|---|---|
n | mean | SD | n | mean | SD | p-valuem | |
Serum phosphorus, mg/dL | |||||||
Baseline | 40 | 7.0 | 0.7 | – | – | – | – |
Week 8 | 39 | 5.5 | 1.3 | 39 | − 1.5 | 1.6 | < 0.0001 |
Week 16 | 33 | 5.6 | 1.5 | 33 | − 1.4 | 1.8 | < 0.0001 |
Corrected serum calcium, mg/dL | |||||||
Baseline | 40 | 8.6 | 0.9 | – | – | – | – |
Week 8 | 39 | 8.6 | 0.8 | 39 | 0.0 | 1.0 | 0.8459 |
Week 16 | 33 | 8.7 | 0.7 | 33 | 0.2 | 0.9 | 0.3332 |
Calcium-phosphorus products, mg2/dL2 | |||||||
Baseline | 40 | 59.8 | 8.4 | – | – | – | – |
Week 8 | 39 | 46.8 | 9.8 | 39 | − 13.1 | 13.0 | < 0.0001 |
Week 16 | 33 | 48.6 | 12.4 | 33 | − 11.7 | 16.4 | 0.0003 |
Serum intact-PTHa, pg/mL | |||||||
Baseline | 25 | 262.3 | 191.5 | – | – | – | – |
Week 8 | 19 | 243.6 | 193.9 | 19 | − 24.0 | 108.5 | 0.3477 |
Week 16 | 22 | 336.1 | 589.3 | 17 | − 50.4 | 137.7 | 0.1511 |
FGF23b, pg/mL | |||||||
Baseline | 40 | 15,282.3 | 13,548.6 | – | – | – | – |
Week 16 | 33 | 10,999.7 | 10,594.0 | 33 | − 4487.8 | 12,122.0 | 0.0412 |
Hbc, g/dL | |||||||
Baseline | 40 | 11.1 | 1.1 | ||||
Week 8 | 39 | 12.6 | 1.1 | 39 | 1.5 | 1.5 | < 0.0001 |
Week 16 | 33 | 12.7 | 1.2 | 33 | 1.7 | 1.8 | < 0.0001 |
RBCd, × 10−4/μL | |||||||
Baseline | 40 | 393.6 | 40.2 | – | – | – | – |
Week 8 | 39 | 419.1 | 45.7 | 39 | 25.5 | 36.2 | < 0.0001 |
Week 16 | 33 | 410.5 | 53.0 | 33 | 18.8 | 53.1 | 0.0500 |
Hte, % | |||||||
Baseline | 40 | 34.9 | 3.1 | – | – | – | – |
Week 8 | 39 | 39.3 | 3.7 | 39 | 4.3 | 4.4 | < 0.0001 |
Week 16 | 33 | 38.8 | 4.0 | 33 | 4.3 | 5.4 | < 0.0001 |
Cumulative dose of ESAsf, IU | |||||||
Baselineh | 40 | 24,050.0 | 18,594.1 | – | – | – | – |
Week 4i | 38 | 24,236.8 | 20,653.1 | 38 | − 526.3 | 12,019.1 | 0.7887 |
Week 8j | 37 | 26,533.8 | 21,679.5 | 37 | 1533.8 | 9123.4 | 0.3133 |
Week 12k | 39 | 15,762.8 | 15,613.6 | 39 | − 8493.6 | 14,897.5 | 0.0010 |
Week 16 l | 34 | 14,985.3 | 15,135.9 | 34 | − 9544.1 | 20,983.4 | 0.0122 |
Cumulative dose of IV-irong, mg | |||||||
Baselineh | 40 | 20.0 | 53.6 | – | – | – | – |
Week 4i | 38 | 14.7 | 38.8 | 38 | − 6.3 | 41.1 | 0.3496 |
Week 8j | 37 | 3.2 | 19.7 | 37 | − 18.4 | 60.1 | 0.0709 |
Week 12k | 39 | 0.0 | 0.0 | 39 | − 20.5 | 54.2 | 0.0233 |
Week 16 l | 34 | 10.6 | 61.7 | 34 | − 8.2 | 83.4 | 0.5688 |
Daily dose of calcium carbonate, g | |||||||
Baseline | 40 | 1.3 | 1.2 | – | – | – | – |
Week 4 | 38 | 1.3 | 1.2 | 38 | 0.0 | 0.4 | 0.5706 |
Week 8 | 39 | 1.5 | 1.2 | 39 | 0.2 | 0.6 | 0.0577 |
Week 12 | 40 | 1.4 | 1.2 | 40 | 0.1 | 0.8 | 0.6348 |
Week 16 | 33 | 1.4 | 1.2 | 33 | 0.1 | 0.9 | 0.3786 |
Daily dose of sucroferric oxyhydroxide, mg | |||||||
Baseline | 40 | 1000.0 | 477.0 | – | – | – | – |
Week 4 | 38 | 1256.6 | 613.7 | 38 | 243.4 | 549.8 | 0.0097 |
Week 8 | 39 | 1282.1 | 626.1 | 39 | 269.2 | 591.6 | 0.0072 |
Week 12 | 40 | 1250.0 | 718.3 | 40 | 250.0 | 662.6 | 0.0220 |
Week 16 | 34 | 1323.5 | 727.0 | 34 | 294.1 | 672.7 | 0.0156 |