The efficacy of high-dose penicillin G for pneumococcal pneumonia diagnosed based on initial comprehensive assessment at admission: an observational study

Table 3 Clinical outcomes of 70 pneumococcal pneumonia cases diagnosed based on clinical judgment at admission

Characteristics	Number of patients (% [95% CI])
Characteristics	Total, N = 70
Primary outcome
Clinical success until day 6^a	61 (87.1 [79.1 to 95.2])
Secondary outcomes
Adverse drug events due to penicillin G	0 (0.0 [0.0 to 0.0])
Switch to other antibiotics^b	4 (5.7 [0.1 to 11.3])^b
30-day mortality	1 (1.4 [− 1.4 to 4.3])^c
In-hospital death	2 (2.9 [− 1.1 to 6.9])^{c, d}
Readmission within 30 days	1 (1.4 [− 1.4 to 4.3])

^aClinical success was defined as the condition in which all the following threshold values were achieved for a 24-h period: temperature, ≤ 37.2 °C; heart rate, ≤ 100 beats/min; respiratory rate, ≤ 24 breaths/min; systolic blood pressure, ≥ 90 mmHg; oxygen saturation, ≥ 90% or arterial oxygen partial pressure, and ≥ 60 mmHg when the patient was not receiving supplemental oxygen
^bThis value includes cases in which penicillin G was replaced by other antibiotics because of pneumonia treatment failure (more detailed information was described in an Additional file 2)
^cThis patient died due to hospital-acquired pneumonia after recovery from community- acquired pneumonia
^dThis patient died due to the complication of acute respiratory distress syndrome in influenza A pneumonia derived from an in-hospital influenza outbreak

ISSN: 1756-0500