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Table 2 M. tuberculosis strains resistant to hexapeptide inhibitor compounds

From: Identification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis

Strain

Compound

MIC99 (µM)

WT

MSD-045

1.6

LP-0458690-RM1

MSD-045

13

LP-0458690-RM2

MSD-045

25

LP-0458690-RM3

MSD-045

25

LP-0458690-RM4

MSD-045

25

LP-0458690-RM5

MSD-045

25

LP-0458690-RM6

MSD-045

25

WT

MSD-099

0.8

LP-0458686-RM1

MSD-099

3.1

LP-0458686-RM2

MSD-099

3.1

LP-0458686-RM3

MSD-099

3.1

  1. MIC99 were determined against M. tuberculosis resistant isolates on solid medium after 3–4 weeks. MIC99 was determined by the serial proportion method and defined as the minimum concentration required to prevent 99% growth [13]