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Table 3 Association of p53 expression intensity with clinicopathologic parameters of head and neck Squamous cell carcinoma

From: Immunohistochemical over expression of p53 in head and neck Squamous cell carcinoma: clinical and prognostic significance

 

n (%)

P-value

Power of test (%)

No intensity (n = 30)

Weak (n = 13)

Intermediate (n = 30)

Strong (n = 48)

Total (n = 121)

Age group (years)

 ≤ 30

3 (10)

0 (0)

1 (3.3)

1 (2.1)

5 (4.1)

0.445

43.47

 31–50

15 (50)

8 (61.5)

11 (36.7)

24 (50)

58 (47.9)

 > 50

12 (40)

5 (38.5)

18 (60)

23 (47.9)

58 (47.9)

Gender

 Male

25 (83.3)

11 (84.6)

22 (73.3)

31 (64.6)

89 (73.6)

0.269

38.17

 Female

5 (16.7)

2 (15.4)

8 (26.7)

17 (35.4)

32 (26.4)

Nodal stage

 N0

17 (56.7)

9 (69.2)

22 (73.3)

19 (39.6)

67 (55.4)

0.053

82.44

 N1

8 (26.7)

0 (0)

2 (6.7)

8 (16.7)

18 (14.9)

 N2a

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

 N2b

5 (16.7)

4 (30.8)

6 (20)

17 (35.4)

32 (26.4)

 N2c

0 (0)

0 (0)

0 (0)

3 (6.3)

3 (2.5)

 N3

0 (0)

0 (0)

0 (0)

1 (2.1)

1 (0.8)

Extranodal extension

 Not present

22 (73.3)

11 (84.6)

28 (93.3)

29 (60.4)

90 (74.4)

0.008

81.53

 Present

8 (26.7)

2 (15.4)

2 (6.7)

19 (39.6)

31 (25.6)

Histologic grade

 Grade-I

6 (20)

7 (53.8)

12 (40)

8 (16.7)

33 (27.3)

0.046

74.91

 Grade-II

20 (66.7)

4 (30.8)

14 (46.7)

35 (72.9)

73 (60.3)

 Grade-III

4 (13.3)

2 (15.4)

4 (13.3)

5 (10.4)

15 (12.4)

  1. Chi square test was applied
  2. P-value ≤ 0.05 considered as significant