Clinicopathologic features and prognostic grouping of gastrointestinal stromal tumors (GISTs) in Pakistani patients: an institutional perspective

Table 3 Immunohistochemal features of gastrointestinal tumors (GISTs)

	S100				ASMA				CD34				CD117
	P (n = 12)	N (n = 28)	ND (n = 8)	P-value	P (n = 19)	N (n = 24)	ND (n = 5)	P-value	P (n = 34)	N (n = 12)	ND (n = 2)	P-value	P (n = 46)	N (n = 2)	P-value
Site	7 (58.3)	18 (64.3)	5 (62.5)	0.515	10 (52.6)	17 (70.8)	3 (60.0)	0.469	25 (73.5)	3 (25.0)	2 (100)	0.013*	28 (60.9)	2 (100)	1.000
Stomach (n = 30)	3 (25.0)	4 (14.3)	3 (37.5)		4 (21.1)	4 (16.7)	2 (40.0)		6 (17.6)	4 (33.3)	0		10 (21.7)	0
Small intestine (n = 10)	2 (16.7)	6 (21.4)	0		5 (26.3)	3 (12.5)	0		3 (8.8)	5 (41.7)	0		8 (17.4)	0
Large intestine (n = 8)
Morphology
Spindle cell (n = 37)	9 (75)	21 (75.0)	7 (87.5)	1.000	12 (63.2)	20 (83.3)	5 (100)	0.462	25 (73.5)	10 (83.3)	2 (100)	0.137	37 (80.4)	0	0.024*
Eptheloid (n = 3)	1 (8.3)	2 (7.1)	0		2 (10.5)	1 (4.2)	0		1 (2.9)	2 (16.7)	0		2 (4.3)	1 (50.0)
Mixed (n = 8)	2 (16.7)	5 (17.9)	1 (12.5)		5 (26.3)	3 (12.5)	0		8 (23.5)	0	0		7 (15.2)	1 (50.0)
Grade
Low (n = 29)	5 (41.7)	17 (60.7)	7 (87.5)	0.123	11 (57.9)	13 (54.2)	5 (100)	0.220	23 (67.6)	5 (41.7)	1 (50.0)	0.263	29 (63.0)	0	0.152
High (n = 19)	7 (58.3)	11 (39.3)	1 (12.5)	0.123	8 (42.1)	11 (45.8)	0	0.220	11 (32.4)	7 (58.3)	1 (50.0)	0.263	17 (37.0)	2 (100.0)	0.152
Prognostic group
Very low risk (n = 5)	0	4 (14.3)	1 (12.5)	0.668	1 (5.3)	3 (12.5)	1 (20)	0.681	4 (11.8)	0	1 (50.0)	0.190	5 (10.9)	0	1.000
Low risk (n = 11)	2 (16.7)	6 (21.4)	3 (37.5)		6 (31.6)	4 (16.7)	1 (20)		10 (29.4)	1 (8.3)	0		11 (23.9)	0
Moderate risk (n = 5)	1 (8.3)	3 (10.7)	1 (12.5)		2 (10.5)	2 (8.3)	1 (20)		4 (11.8)	1 (8.3)	0		5 (10.9)	0
High risk (n = 27)	9 (75.0)	15 (53.6)	3 (37.5)		10 (52.6)	15 (62.5)	2 (40)		16 (47.1)	10 (83.3)	1 (50.0)		25 (54.3)	2 (100)

ISSN: 1756-0500