Antiplasmodial activity of Vernonia adoensis aqueous, methanol and chloroform leaf extracts against chloroquine sensitive strain of Plasmodium berghei in vivo in mice

Table 3 Effect of V. adoensis of aqueous, methanol and chloroform leaf extracts on the packed cell volume of P. berghei infected Swiss albino mice

Test extracts	Dose (mg/kg/day)	Packed cell volume		% Change
Test extracts	Dose (mg/kg/day)	Before treatment (D₀)	After treatment (D₄)	% Change
Aqueous	NC	51.13 ± 0.62	40.35 ± 0.26*	− 21.08^a
	200	50.83 ± 0.79	50.31 ± 0.93	− 1.02^b
	400	51.42 ± 0.64	50.68 ± 0.63	− 1.44^b
	600	52.30 ± 0.27	51.93 ± 0.36	− 0.71^b
	PC	53.06 ± 0.60	52.84 ± 0.52	− 0.41^b
Methanol	NC	53.2 ± 0.31	43.28 ± 0.85*	− 18.65^a
	200	51.68 ± 0.45	50.81 ± 0.46	− 1.68^b
	400	51.03 ± 0.09	50.29 ± 0.49	− 1.45^b
	600	52.05 ± 0.36	51.38 ± 0.27	− 1.29^b
	PC	50.78 ± 0.39	51.05 ± 0.08	0.53^b
Chloroform	NC	50.92 ± 0.55	44.01 ± 1.53*	− 13.57^a
	200	51.67 ± 0.25	51.02 ± 0.46	− 1.26^b
	400	52.3 ± 0.36	52.12 ± 0.33	− 0.34^b
	600	53.16 ± 0.63	53.13 ± 0.64	− 0.06^b
	PC	51.42 ± 0.35	52.08 ± 0.55	1.28^b

Values are presented as Mean ± SEM
PC, positive control; NC, negative control (0.2 ml of 3% Tween 80)
^a,bValues in the same column followed by the same letter do not differ significantly (P > 0.05)
Values shown by * are significant at P < 0.05