Table 2 Cox-proportional hazard analysis of predictors of TB incidence in children on ART at Debre-Markos Referral Hospital, Northwest Ethiopia from March 2005 to April 2017

Age

 0–5 year

0.860

1.1 (0.4, 3.1)

 5–10 year

0.861

1.1 (0.4, 3.0)

 10–15 year

1

Sex

 Male

1

 Female

0.428

1.4 (0.7, 2.6)

Residence

 Urban

1

1

 Rural

0.051

2.3 (1.0, 5.3)

0.333

1.7 (0.6, 5.0)

Parent status

 Both parents alive

1

1

 Paternal/maternal orphan

0.008

2.7 (1.3, 5.7)

0.875

0.9 (0.4,2.3)

 Double orphan

0.010

3.8 (1.4, 10.3)

0.434

0.6 (0.2,2.1)

WHO clinical stage

 Stage 1 and 2

1

1

 Stage 3 and 4

< 0.001

11.6 (5.5, 24.3)

0.020

3.0 (1.2, 7.7)^*

CD4 count

 Below threshold

0.001

3.4 (1.7, 7.0)

0.157

1.8 (0.8,4.2)

 Above threshold

1

1

Hemoglobin

 < 10 mg/dl

0.001

3.5 (1.7, 7.3)

0.345

1.6 (0.6,3.9)

 ≥ 10 mg/dl

1

1

Nutritional status

 Underweight

0.003

2.8 (1.4, 5.5)

0.757

1.1 (0.5,2.5)

 Normal

1

1

Ever taking CPT

 Yes

1

1

 No

< 0.001

7.2 (3.1,16.8)

0.507

1.4 (0.5,3.9)

Ever taking IPT

 Yes

1

1

 No

0.025

3.0 (1.1,7.7)

0.870

1.1 (0.4,3.1)

Months on care before ART

 ≤ 3 month

1

1

 > 3 month

< 0.001

12.6 (6.2,25.7)

0.006

4.0 (1.5,10.6)^*

ART adherence

 Good

1

1

 Ever had fair and poor

< 0.001

17.4 (8.4,35.9)

0.005

4.0 (1.5,10.8)^*

Months on care after ART

 ≤ 6 month

< 0.001

13.1 (5.2,33.1)

0.011

5.5 (1.5,20.6)^*

 > 6 month

1

1