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Fig. 1 | BMC Research Notes

Fig. 1

From: Immune adaptor protein SKAP1 (SKAP-55) forms homodimers as mediated by the N-terminal region

Fig. 1

SKAP1 and SKAP2 form homodimers. a Model of the structure of SKAP1 and SKAP2. Mutations in the dimerization domain of SKAP-1 A17/F20/L21 is shown. b Co-precipitation of SKAP1 with SKAP-1 and SKAP2 with SKAP2. Left panel: anti-FLAG was used to precipitate antigen from lysates of transfected 293T cells followed by blotting with anti-FLAG or anti-GFP. Lane 1: Flag-SKAP2; lane 2: GFP-SKAP2; lane 3: Flag-SKAP2 and GFP-SKAP2; lane 4: Flag-SKAP1; lane 5: Flag and GFP-SKAP1; lane 6: FlagDM (A17/F20/L21) and GFP-SKAP1. Right panel: blotting of cell lysates from transfected 293T cells seen in left panel

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