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Table 2 Socioeconomic and health characteristics predictors of levels of recruitment for Insight 46, adjusting for sex, childhood and adult SEP and education

From: Using a birth cohort to study brain health and preclinical dementia: recruitment and participation rates in Insight 46

Variable

A. Specific life course data available

B. Willingness for London-clinic

C. Attended

D. Scanned

OR

P

95% CI

OR

P

95% CI

OR

P

95% CI

OR

P

95% CI

Childhood cognitive score

 Bottom 10%

Reference

 

Reference

 

Reference

 

Reference

 

 Middle 80%

1.55

0.01

1.10, 2.19

1.66

0.07

0.96, 2.90

1.06

0.89

0.45, 2.48

1.26

0.84

0.14, 11.54

 Top 10%

1.06

0.79

0.68, 1.65

1.78

0.09

0.92, 3.44

1.28

0.60

0.50, 3.30

2.07

0.57

0.17, 25.65

Word learning test memory score at 69 years

 Bottom 10%

Reference

 

Reference

 

Reference

 

Reference

 

 Middle 80%

1.25

0.16

0.92, 1.70

1.27

0.28

0.82, 1.94

1.40

0.26

0.79, 2.49

1.15

0.86

0.25, 5.29

 Top 10%

1.56

0.07

0.97, 2.50

1.25

0.45

0.71, 2.21

1.77

0.13

0.85, 3.68

1.32

0.78

0.19, 8.94

Mental health prevalence at age 69

 No

Reference

 

Reference

 

Reference

 

Reference

 

 Yes

0.78

0.07

0.59, 1.02

0.91

0.60

0.63, 1.30

0.46

< 0.01

0.29, 0.73

0.28

0.01

0.10, 0.75

Lifetime smoking to 69 years

 Never smoker

Reference

 

Reference

 

Reference

 

Reference

 

 Ex-smoker

0.98

0.86

0.81, 1.19

0.90

0.42

0.70, 1.16

0.99

0.97

0.73, 1.35

0.47

0.11

0.18, 1.18

 Current smoker

0.64

0.01

0.46, 0.88

0.70

0.14

0.43, 1.12

0.48

0.03

0.25, 0.94

0.33

0.21

0.06, 1.86

Alcohol use at age 69

 Never

Reference

 

Reference

 

Reference

 

Reference

 

 Less than once a week

1.09

0.58

0.80, 1.48

0.91

0.63

0.61, 1.35

1.28

0.34

0.77, 2.13

0.32

0.29

0.04, 2.62

 2–3× per week

1.21

0.25

0.87, 1.68

1.22

0.35

0.80, 1.85

1.91

0.02

1.13, 3.25

0.45

0.46

0.05, 3.73

 4+ times per week

1.17

0.35

0.84, 1.61

1.11

0.62

0.74, 1.67

1.29

0.33

0.77, 2.16

0.54

0.57

0.06, 4.63

Overweight at age 69

 No

Reference

 

Reference

 

Reference

 

Reference

 

 Overweight

0.74

0.01

0.58, 0.94

0.89

0.40

0.67, 1.17

1.61

0.01

1.14, 2.28

0.39

0.15

0.10, 1.43

 Obese

0.67

< 0.01

0.52, 0.86

0.95

0.72

0.70, 1.28

1.45

0.05

0.99, 2.12

0.17

0.01

0.05, 0.62

Type II diabetes at age 69

 No

Reference

 

Reference

 

Reference

 

Reference

 

 Yes

0.83

0.18

0.63, 1.09

1.04

0.85

0.70, 1.53

1.21

0.46

0.73, 2.01

0.68

0.50

0.22, 2.06

Hypertension by age 69

 No

Reference

 

Reference

 

Reference

 

Reference

 

 Yes

0.61

< 0.01

0.51, 0.73

0.86

0.21

0.69, 1.09

0.92

0.58

0.69, 1.23

0.98

0.94

0.46, 2.07

Overall disease burden at age 69

None

Reference

 

Reference

 

Reference

 

Reference

 

 1

0.81

0.13

0.62, 1.06

1.31

0.09

0.96, 1.78

0.79

0.24

0.54, 1.16

1.18

0.74

0.45, 3.12

 2

0.70

0.02

0.52, 0.94

1.01

0.94

0.71, 1.44

0.84

0.44

0.53, 1.31

1.15

0.81

0.36, 3.67

 3+

0.72

0.03

0.53, 0.97

1.23

0.28

0.85, 1.77

0.63

0.04

0.40, 0.99

0.71

0.54

0.23, 2.15

Self-rated health at age 68

 Poor

Reference

 

Reference

 

Reference

 

Reference

 

 Fair

1.05

0.85

0.62, 1.80

1.35

0.47

0.59, 3.08

1.40

0.61

0.39, 5.05

0.37

0.22

0.08, 1.81

 Good

1.30

0.31

0.78, 2.17

1.36

0.44

0.62, 2.97

2.66

0.12

0.77, 9.15

0.61

0.47

0.16, 2.35

 Very good

1.93

0.01

1.16, 3.22

1.65

0.21

0.76, 3.58

3.75

0.04

1.10, 12.77

0.91

0.88

0.25, 3.32

 Excellent

1.97

0.02

1.11, 3.50

2.07

0.09

0.89, 4.82

3.42

0.06

0.95, 12.29

1.00

 -

1.00, 1.00

APOE status

 No e4

Reference

 

Reference

 

Reference

 

Reference

 

 e4 heterozygous

0.85

0.13

0.68, 1.05

0.99

0.97

0.75, 1.32

0.98

0.93

0.68, 1.42

1.08

0.88

0.41, 2.80

 e4 homozygous

1.27

0.39

0.73, 2.21

0.79

0.50

0.40, 1.56

0.97

0.95

0.38, 2.46

0.66

0.70

0.08, 5.46

Residential distance to London centre (miles)

 < 60

Reference

 

Reference

 

Reference

 

Reference

 

 60–120

0.99

0.92

0.79, 1.24

0.65

0.01

0.48, 0.90

1.21

0.09

0.96, 2.16

NA

  

 120–180

0.99

0.91

0.78, 1.24

0.40

< 0.01

0.29, 0.55

1.19

0.39

0.80, 1.78

   

 > 180

0.87

0.24

0.68, 1.10

0.36

< 0.01

0.26, 0.50

1.11

0.62

0.73, 1.68

   
  1. SEP: socioeconomic position; OR: odds ratio. A: Comparing those that didn’t meet the specific life course data availability criteria vs those who did; B: comparing those that previously indicated they were not willing to attend a London-based clinic or didn’t respond vs those who were; C: comparing those that didn’t attend vs successfully attended; D: comparing those who were not scanned vs those successfully scanned
  2. Italic values indicate p < 0.05