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Table 3 Summarizing the association of independent variable with ALT/AST level via logistic regression analysis in patients taking HAART compared with treatment naïve controls at Debre Berhan Referral Hospital, Northeast Ethiopia

From: Liver enzyme elevation in patients taking HAART compared with treatment naïve controls at Debre Berhan Referral Hospital: a comparative cross-sectional study, Northeast Ethiopia

Variables

ALT/AST Level

COR

Sig

AOR

Normal

Elevated

Age

 ≤ 35 years

63 (41.4)

14 (9.2)

1

1

1

 > 35 years

63 (41.4)

12 (7.9)

1.167 (0.500–2.210)

0.721

1.152 (0.438–3.031)

Sex

 Male

52 (34.2)

9 (5.9)

1

1

1

 Female

74 (48.7)

17 (11.2)

0.753 (0.312–1.821)

0.529

1.255 (0.427–3.690)

Marital status

 Single

24 (15.8)

4 (2.6)

1

1

1

 Married

54 (35.5)

15 (9.9)

0.600 (0.180–1.998)

0.405

0.510 (0.137–1.908)

 Divorced

28 (18.4)

3 (2)

1.556 (0.316–7.652)

0.587

1.947 (0.311–12.184)

 Widowed

20 (13.2)

4 (2.6)

0.433 (0.140–1.338)

0.813

1.019 (0.178–5.826)

Residence

 Urban

98 (64.5)

23 (15.1)

1

1

1

 Rural

28 (18.4)

3 (2)

2.190 (0.613–7.834)

0.228

0.304 (0.072–1.280)

Educational status

 No formal education

23 (15.1)

9 (5.9)

0.249 (0.069–0.900)

0.034

0.130 (0.029–0.592)

 Primary education

62 (40.8)

13 (8.6)

0.465 (0.142–1.527)

0.207

0.338 (0.092–1.242)

 Secondary and above

41 (27)

4 (2.6)

1

1

1

Clinical stage

 Stage I

45 (29.6)

8 (5.3)

1

1

1

 Stage II

30 (19.7)

6 (3.9)

0.889 (0.280–2.821)

0.842

1.491 (0.364–6.108)

 Stage III

42 (27.6)

11 (7.2)

0.679(0.249–1.851)

0.449

0.607 (0.193–1.908)

 Stage IV

9 (5.9)

1 (0.7)

1.600 (0.178–14.42)

0.675

1.635 (0.151–17.723)

Body mass index

 < 18.5

22 (14.5)

9 (5.9)

1

1

1

 18.6–24.9

88 (57.9)

15 (9.9)

2.400 (0.929–6.201)

0.071a

3.387 (1.119–10.265)

 ≥ 25

16 (10.5)

2 (1.3)

3.273 (0.621–17.247)

0.162

3.333 (0.536–20.733)

CPT-prophylaxis

 Yes

61 (40.1)

18 (11.8)

0.417 (0.169–1.029)

0.058

0.280 (0.093–0.842)

 No

65 (42.8)

8 (5.3)

1

1

1

Regimens

 d4T-3TC-NVP

8 (10.5)

2 (2.6)

1.455 (0.212–9.984)

0.703

2.710 (0.100–73.157)

 d4T-3TC-EFV

2 (2.6)

2 (2.6)

0.364 (0.038–3.518)

0.382

0.308 (0.003–33.145)

 ZDV-3TC-NVP

16 (21.1)

3 (3.9)

1.939 (0.361–10.430)

0.440

5.898 (0.287–121.288)

 ZDV-3TC-EFV

11 (14.5)

3 (3.9)

1.212 (0.216–6.800)

0.827

2.403 (0.133–43.467)

 TDF-3TC-NVP

9 (11.8)

5 (6.6)

0.655 (0.134–3.186)

0.600

0.519 (0.028-9.727)

 TDF-3TC-EFV

11 (14.5)

4 (5.3)

1

1

1

  1. COR crude odd ratio, AOR adjusted odds ratio, d4T stavudine, 3TC lamivudine, NVP nevirapine, EFV efavirenz, ZDV zidovudine, TDF tenofovir
  2. aMultiple logistic regression statically significant, ALT normal value for male ULN ≤ 40 U/L, for female ALT ≤ 35 U/L and AST value for male ≤ 35 U/L and AST value for female ≤ 31 U/L