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Table 1 Baseline demographic and clinical characteristics of study participants by childhood trauma exposure

From: The effect of childhood trauma, ApoE genotype and HIV-1 viral protein R variants on change in cognitive performance

 

All participants (n = 73)

Childhood trauma (n = 54)

No childhood trauma (n = 19)

t

U

χ2

P

Mean age in years ± SD

35.23 ± 7.24

35.81 ± 6.60

33.58 ± 8.80)

–1.16

  

0.250

Median years of education (interquartile range)

11.00 (9.00 –11.00)

10.00 (9.00 –11.00)

11.00 (10.00–12.00)

 

362.00

 

0.052

Median viral load (interquartile range)a

18,459.50 (1732.25–64,831.75)

24,510.00 (4478.00–64,634.50)

9759.00 (1284.50–50,905.50)

 

320.50

 

0.023

Median log-transformed viral load (interquartile range)a

4.26 (3.20 –4.82)

4.39 (3.52 –4.81)

3.99 (3.08–4.87)

 

140.00

 

0.332

Median CD4 count (interquartile range)

453.00 (270.50–664.25)

432.00 (259.50–643.75)

481.50 (410.25–677.75)

 

412.00

 

0.336

Median CD8 count (range)

834.00 (620.50–1107.75)

768.00 (539.00–1090.00)

1050.00 (754.00–1284.00)

 

357.50

 

0.203

On ART treatment

56

47

9

  

12.38

0.001

AA37 b

     

1.11

0.574

I

3

3

0

    

AA41b

     

2.78

0.427

S

24

20

4

    

N

12

7

5

    

AA55b

     

5.61

0.061

A

13

13

0

    

Hetero- or homozygous for the ApoE ε4 allelec

26

18

8

  

1.72

0.190

Mean baseline global cognitive score ± SD

–0.02 ± 0.55

–0.08 ± 0.54

0.15 ± 0.53

1.61

  

0.112

Mean follow-up global cognitive score ± SD

–0.12 ± 0.53

–0.19 ± 0.55

0.07 ± 0.41

1.88

  

0.064

  1. AA amino acid, ApoE apoliprotein E, ART antiretroviral therapy, SD standard deviation
  2. Parametric and non-parametric data are represented as mean ± SD and median and interquartile range respectively
  3. aViral load comparisons included the 38 participants with a viral load of greater than or equal to 40, the lower limit of sensitivity of the assay
  4. bAmino acid data was available for 66 participants
  5. cApoE ε4 allele comparison included the 63 participants for whom genotype information was available