Table 2 Characteristics and immunological parameters of active and recovered HCV participants
Recovered HCV (N = 41) | Active HCV (N = 122) | P value | |
|---|---|---|---|
Sex | 0.293 | ||
Female (%) | 13 (31.7) | 52 (42.6) | |
Male (%) | 28 (68.3) | 70 (57.4) | |
Age (mean, SD) | 32 (26,38) | 35 (29,43.8) | 0.069 |
HBsAg status | 0.546 | ||
Negative (%) | 35 (87.5) | 111 (91) | |
Positive (%) | 5 (12.5) | 11 (9) | |
HIV status | 0.681 | ||
Negative (%) | 39 (97.5) | 115 (94.3) | |
Positive (%) | 1 (2.5) | 7 (5.7) | |
Alcohol use | 0.551 | ||
No (%) | 35 (85.4) | 97 (79.5) | |
Yes (%) | 6 (14.6) | 25 (20.5) | |
AST (median, IQR) U/L | 26 (14.2,31) | 35 (25,55) | < 0.001* |
ALT (median, IQR) U/L | 27 (7.2,41.5) | 46 (23,70) | < 0.001* |
IL-2 (pg/ml) | 132.4 (71.0–207.1) | 138.7 (81.8–199.0) | 0.718 |
IL-5 (pg/ml) | 44.4 (37.7–76.0) | 49.7 (40.7–73.2) | 0.549 |
IL-10 (pg/ml) | 67.2 (50.6–113.1) | 48.5 (30.3–63.2) | 0.012 |
IL-17A (pg/ml) | 18.6 (9.6) | 18.2 (8.5) | 0.874** |
TNF alpha (ng/L) | 61.6 (22.3–99.5) | 22.7 (0.3–111.9) | 0.125 |
IFN gamma (pg/ml) | 59.4 (8.0–194.0) | 72.8 (34.1–275.8) | 0.573 |